Gain-switched 311-nm Ti:Sapphire laser might be a potential treatment modality for atopic dermatitis.
Phototherapy with 311-nm narrowband-UVB (NBUVB) is an effective adjuvant treatment modality for atopic dermatitis (AD). In this study, we evaluated the therapeutic effect of the newly developed gain-switched 311-nm Ti:Sapphire laser device using a NC/Nga mouse AD model. A total number of 50 mice wer...
| Publicado en: | Lasers in Medical Science Vol. 31; no. 7; pp. 1437 - 1446 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117673393&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117673393 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02688921 O4P jtl: Lasers in Medical Science issn: 02688921 maglogo: N pubinfo: dt: Sep2016 vid: 31 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 117673393 117673393 NLM27394442 117673393 10.1007/s10103-016-2006-8 NLM27394442 117673393 ppf: 1437 ppct: 9 formats: tig: atl: Gain-switched 311-nm Ti:Sapphire laser might be a potential treatment modality for atopic dermatitis. aug: au: Choi, Sun OH, Chang Kwon, Tae-Rin Kwon, Hyun Choi, Eun Jang, Yu-Jin Kim, Hye Chu, Hong Mun, Seog Kim, Myeung Kim, Beom Choi, Sun Young Oh, Chang Taek Kwon, Hyun Jung Choi, Eun Ja Kim, Hye Sung Mun, Seog Kyun Kim, Myeung Nam Kim, Beom Joon affil: Department of Dermatology , Chung-Ang University College of Medicine , Seoul Korea sug: subj: Aluminum Oxide Laser Therapy Dermatitis, Atopic Radiotherapy Animal Studies Models, Biological Hypersensitivity Pathology Inflammation Immunology T Lymphocytes Immunology Hypersensitivity Immunology Skin Pathology Immunoglobulins Skin Radiation Effects Inflammation Pathology Inflammation Mediators Metabolism Mice Cytokines ab: Phototherapy with 311-nm narrowband-UVB (NBUVB) is an effective adjuvant treatment modality for atopic dermatitis (AD). In this study, we evaluated the therapeutic effect of the newly developed gain-switched 311-nm Ti:Sapphire laser device using a NC/Nga mouse AD model. A total number of 50 mice were used in this study. Atopic dermatitis (AD) was induced in mice by exposure to Dermatophagoides farina. These, NC/Nga mice were then treated with conventional 311-nm NBUVB or the newly developed gain-switched 311-nm Ti:Sapphire laser. The clinical features, dermatitis severity scores, and scratching behavior were assessed. In addition, serologic analyses including inflammatory cytokines and histological analyses were performed. Gain-switched 311-nm Ti:Sapphire laser improved the AD-like skin lesions, severity, and symptoms of AD in the NC/Nga mouse model. This new laser also modulated the immune response found in the AD model, including hyper-IgE, upregulated Th2 cytokines, and the Th2-mediated allergic inflammatory reaction. Gain-switched 311-nm Ti:Sapphire laser shows therapeutic promise via an immune-modulation mechanism in an AD mouse model. These data suggest that gain-switched 311-nm Ti:Sapphire laser may be useful as a targeted phototherapy modality for AD. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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