Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study.
Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three...
| Publicado en: | Brain Imaging & Behavior Vol. 10; no. 3; pp. 893 - 901 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117723642&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117723642 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Sep2016 vid: 10 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 117723642 117723642 NLM26589710 117723642 10.1007/s11682-015-9483-4 NLM26589710 117723642 ppf: 893 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study. aug: au: Bernard, Charlotte Catheline, Gwénaëlle Dilharreguy, Bixente Couffinhal, Thierry Ledure, Sylvain Lassalle-Lagadec, Saioa Callaert, Dorothée Allard, Michèle Sibon, Igor Catheline, Gwénaëlle Callaert, Dorothée Allard, Michèle affil: Univ Bordeaux, Centre Hospitalier Universitaire de Bordeaux, Centre d'Exploration, de Prévention et de Traitement de l'Athérosclérose (CEPTA) , Pessac France sug: subj: Acute Coronary Syndrome Psychosocial Factors Executive Function Cerebral Cortex Cognition Disorders Etiology Cognition Disorders Acute Coronary Syndrome Middle Age Prospective Studies Magnetic Resonance Imaging Male Neural Pathways Physiopathology Acute Coronary Syndrome Physiopathology Brain Mapping Neuropsychological Tests Cerebral Cortex Physiopathology Neural Pathways Gray Matter Physiopathology Acute Coronary Syndrome Complications Relaxation Gray Matter Female Cognition Disorders Physiopathology Diagnostic Imaging Human Clinical Assessment Tools Middle Aged: 45-64 years Male Female ab: Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three patients were recruited 4 ± 1 months after a first ACS. Executive functions were evaluated with the Trail-Making-Test-B (TMTB) at baseline (ie 4 ± 1 months after ACS) and 6 months later (ie 10 ± 1 months after ACS). Using both time-points, we identified 3 groups of patients according to normative data based on age, gender and education level: 15 'cognitively normal' patients without impairment at each follow-up, 10 'transient impaired' patients with an impairment only at baseline and 8 'impairing' patients with an impairment only at follow-up. We explored, in the whole-brain, the structural integrity using Voxel-Based Morphometry and Tract-Based Spatial Statistics and the resting-state functional connectivity using Network-Based Statistics. No structural difference was observed between impaired and cognitively normal patients. At the functional level, compared to the 'cognitively normal' group, the 'transient impaired' patients presented an increased functional connectivity in a network centered on middle-orbito-frontal regions, whereas the 'impairing' patients presented only a non-significant decrease of functional connectivity. Executive dysfunction in ACS patients is associated to functional but no structural characteristics, particularly to an increased functional connectivity in cognitive networks in transient impaired patients. Further studies with larger sample size are needed to confirm these results and to determine if these patients could be at higher risk for developing permanent cognitive disorders. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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