Male brain ages faster: the age and gender dependence of subcortical volumes.
Effects of gender on grey matter (GM) volume differences in subcortical structures of the human brain have consistently been reported. Recent research evidence suggests that both gender and brain size influences volume distribution in subcortical areas independently. The goal of this study was to de...
| Publicado en: | Brain Imaging & Behavior Vol. 10; no. 3; pp. 901 - 911 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Sep2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117723643&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117723643 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Sep2016 vid: 10 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 117723643 117723643 NLM26572143 117723643 10.1007/s11682-015-9468-3 NLM26572143 117723643 ppf: 901 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Male brain ages faster: the age and gender dependence of subcortical volumes. aug: au: Király, András Szabó, Nikoletta Tóth, Eszter Csete, Gergő Faragó, Péter Kocsis, Krisztián Must, Anita Vécsei, László Kincses, Zsigmond Király, András Szabó, Nikoletta Tóth, Eszter Csete, Gergő Faragó, Péter Kocsis, Krisztián Vécsei, László Kincses, Zsigmond Tamás affil: Department of Neurology, Albert Szent-Györgyi Clinical Center , University of Szeged , Semmelweis u. 6 Szeged H-6725 Hungary sug: subj: Reproduction Aging Brain Aging Physiology Brain Physiology Male Middle Age Multivariate Analysis Information Science Gray Matter Female Young Adult Image Processing, Computer Assisted Gray Matter Physiology Human Body Weights and Measures Adult Validation Studies Comparative Studies Evaluation Research Multicenter Studies Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: Effects of gender on grey matter (GM) volume differences in subcortical structures of the human brain have consistently been reported. Recent research evidence suggests that both gender and brain size influences volume distribution in subcortical areas independently. The goal of this study was to determine the effects of the interplay between brain size, gender and age contributing to volume differences of subcortical GM in the human brain. High-resolution T1-weighted images were acquired from 53 healthy males and 50 age-matched healthy females. Total GM volume was determined using voxel-based morphometry. We used model-based subcortical segmentation analysis to measure the volume of subcortical nuclei. Main effects of gender, brain volume and aging on subcortical structures were examined using multivariate analysis of variance. No significant difference was found in total brain volume between the two genders after correcting for total intracranial volume. Our analysis revealed significantly larger hippocampus volume for females. Additionally, GM volumes of the caudate nucleus, putamen and thalamus displayed a significant age-related decrease in males as compared to females. In contrast to this only the thalamic volume loss proved significant for females. Strikingly, GM volume decreases faster in males than in females emphasizing the interplay between aging and gender on subcortical structures. These findings might have important implications for the interpretation of the effects of unalterable factors (i.e. gender and age) in cross-sectional structural MRI studies. Furthermore, the volume distribution and changes of subcortical structures have been consistently related to several neuropsychiatric disorders (e.g. Parkinson's disease, attention deficit hyperactivity disorder, etc.). Understanding these changes might yield further insight in the course and prognosis of these disorders. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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