Altered neural activation during prepotent response inhibition in breast cancer survivors treated with chemotherapy: an fMRI study.
While impairments in executive functions have been reported in breast cancer survivors (BCS) who have undergone adjuvant chemotherapy, only a limited number of functional neuroimaging studies have associated alterations in cerebral activity with executive functions deficits in BCS. Using fMRI, the c...
| Published in: | Brain Imaging & Behavior Vol. 10; no. 3; pp. 840 - 849 |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Springer Nature
Sep2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117723646&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117723646 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Sep2016 vid: 10 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 117723646 117723646 NLM26489975 117723646 10.1007/s11682-015-9464-7 NLM26489975 117723646 ppf: 840 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Altered neural activation during prepotent response inhibition in breast cancer survivors treated with chemotherapy: an fMRI study. aug: au: Kam, Julia Boyd, Lara Hsu, Chun Liu-Ambrose, Teresa Handy, Todd Lim, Howard Hayden, Sherri Campbell, Kristin Kam, Julia W Y Boyd, Lara A Hsu, Chun L Handy, Todd C Lim, Howard J Campbell, Kristin L affil: Department of Psychology , University of British Columbia , 2136 West Mall Vancouver Canada V6T 1Z4 sug: subj: Brain Drug Effects Breast Neoplasms Therapy Behavior Antineoplastic Agents Adverse Effects Cognition Disorders Etiology Breast Neoplasms Psychosocial Factors Neuropsychological Tests Cerebrovascular Circulation Drug Effects Antineoplastic Agents Therapeutic Use Breast Neoplasms Survivors Brain Cognition Disorders Treatment Outcomes Female Executive Function Drug Effects Cognition Disorders Physiopathology Cerebrovascular Circulation Physiology Reaction Time Magnetic Resonance Imaging Breast Neoplasms Physiopathology Middle Age Brain Physiopathology Executive Function Brain Mapping Oxygen Blood Chemotherapy, Adjuvant Human Middle Aged: 45-64 years Female ab: While impairments in executive functions have been reported in breast cancer survivors (BCS) who have undergone adjuvant chemotherapy, only a limited number of functional neuroimaging studies have associated alterations in cerebral activity with executive functions deficits in BCS. Using fMRI, the current study assessed the neural basis underlying a specific facet of executive function, namely prepotent response inhibition. 12 BCS who self-reported cognitive problems up to 3 years following cancer treatment and 12 female healthy comparisons (HC) performed the Stroop task. We compared their neural activation between the incongruent and neutral experimental conditions. Relative to the HC group, BCS showed lower blood-oxygen level dependent signal in several frontal regions, including the anterior cingulate cortex, a region critical for response inhibition. Our data indicates reduced neural activation in BCS during a prepotent response inhibition task, providing support for the prevailing notion of neural alterations observed in BCS treated with chemotherapy. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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