Abnormal prefrontal cortex resting state functional connectivity and severity of internet gaming disorder.
Internet Gaming Disorder (IGD) among adolescents has become an important public concern and gained more and more attention internationally. Recent studies focused on IGD and revealed brain abnormalities in the IGD group, especially the prefrontal cortex (PFC). However, the role of PFC-striatal circu...
| Published in: | Brain Imaging & Behavior Vol. 10; no. 3; pp. 719 - 730 |
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| Main Authors: | , , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Springer Nature
Sep2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117723659&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117723659 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Sep2016 vid: 10 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 117723659 117723659 NLM26311395 117723659 10.1007/s11682-015-9439-8 NLM26311395 117723659 ppf: 719 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Abnormal prefrontal cortex resting state functional connectivity and severity of internet gaming disorder. aug: au: Jin, Chenwang Zhang, Ting Cai, Chenxi Bi, Yanzhi Li, Yangding Yu, Dahua Zhang, Ming Yuan, Kai affil: Department of Medical Imaging, the First Affiliated Hospital of Medical College , Xi'an Jiaotong University , Xi'an China sug: subj: Internet Behavior, Addictive Frontal Lobe Behavior, Addictive Physiopathology Frontal Lobe Physiopathology Neural Pathways Brain Mapping Young Adult Adolescence Psychological Tests Gray Matter Physiopathology Severity of Illness Indices Magnetic Resonance Imaging Neural Pathways Physiopathology Cross Sectional Studies Relaxation Female Male Body Weights and Measures Gray Matter Human Adolescent: 13-18 years Female Male ab: Internet Gaming Disorder (IGD) among adolescents has become an important public concern and gained more and more attention internationally. Recent studies focused on IGD and revealed brain abnormalities in the IGD group, especially the prefrontal cortex (PFC). However, the role of PFC-striatal circuits in pathology of IGD remains unknown. Twenty-five adolescents with IGD and 21 age- and gender-matched healthy controls were recruited in our study. Voxel-based morphometric (VBM) and functional connectivity analysis were employed to investigate the abnormal structural and resting-state properties of several frontal regions in individuals with online gaming addiction. Relative to healthy comparison subjects, IGD subjects showed significant decreased gray matter volume in PFC regions including the bilateral dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC), anterior cingulate cortex (ACC) and the right supplementary motor area (SMA) after controlling for age and gender effects. We chose these regions as the seeding areas for the resting-state analysis and found that IGD subjects showed decreased functional connectivity between several cortical regions and our seeds, including the insula, and temporal and occipital cortices. Moreover, significant decreased functional connectivity between some important subcortical regions, i.e., dorsal striatum, pallidum, and thalamus, and our seeds were found in the IGD group and some of those changes were associated with the severity of IGD. Our results revealed the involvement of several PFC regions and related PFC-striatal circuits in the process of IGD and suggested IGD may share similar neural mechanisms with substance dependence at the circuit level. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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