New Concepts on Pathogenesis and Diagnosis of Liver Fibrosis; A Review Article.
Liver fibrosis is a potentially reversible response to hepatic insults, triggered by different chronic diseases most importantly viral hepatitis, alcoholic, and nonalcoholic fatty liver disease. In the course of the chronic liver disease, hepatic fibro-genesis may develop, which is attributed to var...
| Publicado en: | Middle East Journal of Digestive Diseases Vol. 8; no. 3; pp. 166 - 179 |
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| Autores principales: | , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Iranian Association of Gastroenterology & Hepatology
Jul2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117794709&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117794709 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20085230 BG4K jtl: Middle East Journal of Digestive Diseases issn: 20085230 maglogo: N pubinfo: dt: Jul2016 vid: 8 iid: 3 pid: 70725 pub: Iranian Association of Gastroenterology & Hepatology artinfo: ui: 117794709 117794709 117794709 10.15171/mejdd.2016.29 117794709 ppf: 166 ppct: 13 formats: fmt: @attributes: type: P tig: atl: New Concepts on Pathogenesis and Diagnosis of Liver Fibrosis; A Review Article. aug: au: Ebrahimi, Hedyeh Naderian, Mohammadreza Sohrabpour, Amir Ali affil: Liver and Pancreaticobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran sug: subj: Liver Cirrhosis Diagnosis Fibrosis Pathology Chronic Disease Epithelial Cells Extracellular Space Biopsy, Needle Disease Progression Regression ab: Liver fibrosis is a potentially reversible response to hepatic insults, triggered by different chronic diseases most importantly viral hepatitis, alcoholic, and nonalcoholic fatty liver disease. In the course of the chronic liver disease, hepatic fibro-genesis may develop, which is attributed to various types of cells, molecules, and pathways. Activated hepatic stellate cell (HSC), the primary source of extracellular matrix (ECM), is fundamental in pathophysiology of fibrogenesis, and thus is the most attractable target for reversing liver fibrosis. Although, liver biopsy has long been considered as the gold standard for diagnosis and staging of hepatic fibrosis, assessing progression and regression by biopsy is hampered by its limitations. We provide recent views on noninvasive approaches including serum biomarkers and radiologic techniques. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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