The effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects: a systematic review with meta-analysis.
Purpose: The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects. Methods: The search process was based on the selection of publications (DB-RCT and RCT) listed in the following databases: PubM...
| Publicado en: | European Journal of Nutrition Vol. 55; no. 6; pp. 2163 - 2177 |
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| Autores principales: | , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117807981&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117807981 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Sep2016 vid: 55 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 117807981 117807981 117807981 10.1007/s00394-015-1089-5 117807981 ppf: 2163 ppct: 14 formats: fmt: @attributes: type: P tig: atl: The effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects: a systematic review with meta-analysis. aug: au: Jamka, Małgorzata Woźniewicz, Małgorzata Walkowiak, Jarosław Bogdański, Paweł Jeszka, Jan Stelmach-Mardas, Marta affil: Department of Human Nutrition and Hygiene , Poznan University of Life Sciences , 31 Wojska Polskiego Str. 60-624 Poznan Poland sug: subj: Vitamin D Administration and Dosage Inflammation Biological Markers Blood Obesity Human Professional Practice, Evidence-Based Systematic Review Meta Analysis Dietary Supplementation PubMed Cochrane Library Embase Research Methodology Evaluation Study Design Evaluation Scales Randomized Controlled Trials Evaluation Adolescence Young Adult Adult Middle Age Aged Male Female Vitamin D Blood C-Reactive Protein Blood Tumor Necrosis Factor Blood Interleukins Blood Vitamin D Deficiency Confidence Intervals P-Value Descriptive Statistics Effect Size Data Analysis Software Regression Medline Child Vitamin D Pharmacodynamics Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Child: 6-12 years Male Female ab: Purpose: The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects. Methods: The search process was based on the selection of publications (DB-RCT and RCT) listed in the following databases: PubMed, Web of Knowledge, Scopus, the Cochrane Library and Embase. To assess the study quality, a nine-point scoring system according to the Newcastle-Ottawa scale was used, and a high-quality study was defined by a threshold of ≥7 points. Thirteen randomized controlled trials were included. The analysed population consisted of 1955 overweight and obese subjects. The mean age ranged from 13.6 to 71.7 years. Changes in the concentration of 25-hydroxycholecalciferol (25(OH)D), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were assessed. To combine individual study results, a meta-analysis was performed. Results: The baseline levels of 25(OH)D suggested vitamin D deficiency or insufficiency in the analysed population. The vitamin D supplementation did not influence on CRP (std. mean differences −0.11; 95 % CI −0.27-0.04; p = 0.15), TNF-α (std. mean differences −0.13; 95 % CI −0.38-0.12; p = 0.31) and IL-6 concentrations (std. mean differences 0.1; 95 % CI −0.43-0.63; p = 0.71). Conclusions: This meta-analysis suggests that supplementation with vitamin D does not have a significant influence on changes in the concentration of selected inflammatory biomarkers in the obese and overweight subjects. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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