Disproportionately increased 24-h energy expenditure and fat oxidation in young men with low birth weight during a high-fat overfeeding challenge.
Background: Low birth weight (LBW) associates with increased risk of developing type 2 diabetes. LBW individuals exhibit disproportionately reduced peripheral insulin action and increased fat oxidation after a 5-day high-fat overfeeding (HFO) challenge. Furthermore, LBW men exhibit increased nocturn...
| Publicado en: | European Journal of Nutrition Vol. 55; no. 6; pp. 2045 - 2053 |
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| Autores principales: | , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Sep2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117807992&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117807992 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Sep2016 vid: 55 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 117807992 117807992 117807992 10.1007/s00394-015-1018-7 117807992 ppf: 2045 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Disproportionately increased 24-h energy expenditure and fat oxidation in young men with low birth weight during a high-fat overfeeding challenge. aug: au: Brøns, Charlotte Lilleøre, Søren Astrup, Arne Vaag, Allan affil: Novo Nordisk A/S , Novo Allé 2880 Bagsværd Denmark sug: subj: Birth Weight Energy Metabolism Dietary Fats Administration and Dosage Oxidation-Reduction Fats Metabolism Human Denmark Funding Source Male Men's Health Metabolic Syndrome X Risk Factors Infant, Low Birth Weight Infant Infant, Newborn Calorimetry Respiratory Quotient Evaluation Body Composition Evaluation Time Factors Glucose Metabolism Dietary Fats Pharmacokinetics Body Mass Index Evaluation Randomized Controlled Trials Random Assignment Intervention Trials Pretest-Posttest Design Crossover Design Absorptiometry, Photon T-Tests Power Analysis Thermogenesis Evaluation Postprandial Period Descriptive Statistics Data Analysis Software P-Value Body Weights and Measures Adipose Tissue Distribution Evaluation Young Adult Infant: 1-23 months Infant, Newborn: birth-1 month Male ab: Background: Low birth weight (LBW) associates with increased risk of developing type 2 diabetes. LBW individuals exhibit disproportionately reduced peripheral insulin action and increased fat oxidation after a 5-day high-fat overfeeding (HFO) challenge. Furthermore, LBW men exhibit increased nocturnal fat oxidation during energy balance and low energy expenditure (EE) during fasting. We hypothesized that short-term HFO could further unmask key defects of whole-body energy metabolism in LBW men. Methods: Eighteen LBW (2717 ± 268 g) and 26 normal birth weight (NBW) (3893 ± 207 g) healthy young men were included in a 5-day HFO (60 E % fat, +50 % calories) study. The 24-h EE, respiratory quotient and substrate oxidation rates were assessed by indirect calorimetry using respiratory chambers. Results: After adjusting for body composition, the LBW subjects displayed increased nighttime EE ( P = 0.02) compared with NBW controls during HFO. Nighttime glucose oxidation rate was decreased ( P = 0.06, adjusted P = 0.05), while both adjusted 24-h ( P = 0.07) and nighttime ( P = 0.02) fat oxidation rate was elevated in LBW subjects. The relative contribution of fat oxidation to EE was increased in LBW compared with NBW men during the entire 24-h period ( P = 0.06) and during nighttime ( P = 0.03). Conclusions: We suggest that disproportionally enhanced fat oxidation in LBW individuals during short-term HFO represents a compensatory response to reduced subcutaneous adipose tissue expandability and storage capacity. The extent to which this mechanism may lead to, or be replaced by insulin resistance, ectopic fat accumulation and/or glucose intolerance during long-term HFO in LBW needs further studies. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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