Diagnosing native liver fibrosis and esophageal varices using liver and spleen stiffness measurements in biliary atresia: a pilot study.
Background: Biliary atresia commonly leads to liver fibrosis and cirrhotic complications, including esophageal varices.Objective: To evaluate liver and spleen stiffness measurements using acoustic radiation force impulse (ARFI) imaging for diagnosing grade of liver fibrosis and predicting the presen...
| Publicado en: | Pediatric Radiology Vol. 46; no. 10; pp. 1409 - 1418 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117808935&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117808935 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Sep2016 vid: 46 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 117808935 117808935 NLM27300741 10.1007/s00247-016-3637-4 NLM27300741 117808935 ppf: 1409 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Diagnosing native liver fibrosis and esophageal varices using liver and spleen stiffness measurements in biliary atresia: a pilot study. aug: au: Tomita, Hirofumi Ohkuma, Kiyoshi Masugi, Yohei Hosoe, Naoki Hoshino, Ken Fuchimoto, Yasushi Fujino, Akihiro Shimizu, Takahiro Kato, Mototoshi Fujimura, Takumi Ishihama, Hideo Takahashi, Nobuhiro Tanami, Yutaka Ebinuma, Hirotoshi Saito, Hidetsugu Sakamoto, Michiie Nakano, Miwako Kuroda, Tatsuo affil: Department of Radiology , Keio University School of Medicine , 35 Shinanomachi Tokyo 160-8582 Japan sug: subj: Esophageal and Gastric Varices Liver Cirrhosis Ultrasonography Biliary Atresia Complications Pilot Studies Female Infant Adolescence Liver Cirrhosis Etiology Biliary Atresia Surgery Male Child Spleen Adult Child, Preschool Esophageal and Gastric Varices Etiology Infant: 1-23 months Adolescent: 13-18 years Child: 6-12 years Adult: 19-44 years Child, Preschool: 2-5 years Female Male ab: Background: Biliary atresia commonly leads to liver fibrosis and cirrhotic complications, including esophageal varices.Objective: To evaluate liver and spleen stiffness measurements using acoustic radiation force impulse (ARFI) imaging for diagnosing grade of liver fibrosis and predicting the presence of esophageal varices in patients treated for biliary atresia.Materials and Methods: ARFI imaging of the spleen and native liver was performed in 28 patients with biliary atresia. We studied the relation between ARFI imaging values and liver histology findings (n=22), upper gastrointestinal endoscopy findings (n=16) and several noninvasive test results. Diagnostic accuracy was assessed using receiver operating characteristic curve analyses.Results: Liver stiffness measurements exhibited a significant difference among the different grades of liver fibrosis (P=0.009), and showed higher values in patients with high-risk esophageal varices than in the other patients (P=0.04). The areas under the receiver operating characteristic curves of liver stiffness measurements for liver fibrosis grades ≥ F2, ≥F3 and = F4 were 0.83, 0.93 and 0.94, respectively. Patients with high-risk esophageal varices were preferentially diagnosed by the combined liver and spleen stiffness measurements (area under the curve, 0.92).Conclusion: Liver and spleen stiffness measurements using ARFI imaging are potential noninvasive markers for liver fibrosis and esophageal varices in patients treated for biliary atresia. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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