Edited Magnetic Resonance Spectroscopy Detects an Age-Related Decline in Nonhuman Primate Brain GABA Levels.
Recent research had shown a correlation between aging and decreasing Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain. However, how GABA level varies with age in the medial portion of the brain has not yet been studied. The purpose of this study was to investigate...
| Publicado en: | BioMed Research International Vol. 2016; pp. 1 - 8 |
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| Autores principales: | , , |
| Formato: | diagnostic images research tables/charts tracings Journal Article |
| Publicado: |
Wiley-Blackwell
8/31/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117854549&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117854549 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 8/31/2016 vid: 2016 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 117854549 117854549 117854549 10.1155/2016/6523909 117854549 ppf: 1 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Edited Magnetic Resonance Spectroscopy Detects an Age-Related Decline in Nonhuman Primate Brain GABA Levels. aug: au: He, Xuanzi Koo, Bang-Bon Killiany, Ronald J. affil: Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA sug: subj: Brain Analysis Aging Evaluation Magnetic Resonance Spectroscopy GABA Analysis Animal Studies Creatinine Primates Magnetic Resonance Imaging Descriptive Statistics T-Tests Pearson's Correlation Coefficient Two-Tailed Test Age Factors ab: Recent research had shown a correlation between aging and decreasing Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain. However, how GABA level varies with age in the medial portion of the brain has not yet been studied. The purpose of this study was to investigate the GABA level variation with age focusing on the posterior cingulate cortex, which is the “core hub” of the default mode network. In this study, 14 monkeys between 4 and 21 years were recruited, and MEGA-PRESS MRS was performed to measure GABA levels, in order to explore a potential link between aging and GABA. Our results showed that a correlation between age and GABA+/Creatine ratio was at the edge of significance (r=-0.523, p=0.081). There was also a near-significant trend between gray matter/white matter ratio and the GABA+/Creatine ratio (r=-0.518, p=0.0848). Meanwhile, the correlation between age and grey matter showed no significance (r=-0.028, p=0.93). Therefore, age and gray matter/white matter ratio account for different part of R-squared (adjusted R-squared = 0.5187) as independent variables for predicting GABA levels. Adjusted R-squared is about 0.5 for two independent variables. These findings suggest that there is internal neurochemical variation of GABA levels in the nonhuman primates associated with normal aging and structural brain decline. pubtype: Academic Journal doctype: diagnostic images research tables/charts tracings Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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