Next-Generation Sequencing Informatics.
Context.--Next-generation sequencing (NGS) is revolutionizing the discipline of laboratory medicine, with a deep and direct impact on patient care. Although it empowers clinical laboratories with unprecedented genomic sequencing capability, NGS has brought along obvious and obtrusive informatics cha...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 140; no. 9; pp. 958 - 976 |
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| Autores principales: | , , , , , , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
College of American Pathologists
Sep2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117888256&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117888256 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Sep2016 vid: 140 iid: 9 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 117888256 117888256 117888256 10.5858/arpa.2015-0507-RA 117888256 ppf: 958 ppct: 18 formats: fmt: @attributes: type: P tig: atl: Next-Generation Sequencing Informatics. aug: au: Roy, Somak LaFramboise, William A. Nikiforov, Yuri E. Nikiforova, Marina N. Routbort, Mark J. Pfeifer, John Nagarajan, Rakesh Carter, Alexis B. Pantanowitz, Liron affil: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania sug: subj: Sequence Analysis Methods Bioinformatics Medical Informatics Sequence Analysis History Quality Control (Technology) Data Analysis Specimen Handling Access to Information Clinical Laboratory Information Systems Systems Design Computer Storage Devices Data Security Computers and Computerization Data Analytics Information Systems Equipment and Supplies ab: Context.--Next-generation sequencing (NGS) is revolutionizing the discipline of laboratory medicine, with a deep and direct impact on patient care. Although it empowers clinical laboratories with unprecedented genomic sequencing capability, NGS has brought along obvious and obtrusive informatics challenges. Bioinformatics and clinical informatics are separate disciplines with typically a small degree of overlap, but they have been brought together by the enthusiastic adoption of NGS in clinical laboratories. The result has been a collaborative environment for the development of novel informatics solutions. Sustaining NGS-based testing in a regulated clinical environment requires institutional support to build and maintain a practical, robust, scalable, secure, and cost-effective informatics infrastructure. Objective.--To discuss the novel NGS informatics challenges facing pathology laboratories today and offer solutions and future developments to address these obstacles. Data Sources.--The published literature pertaining to NGS informatics was reviewed. The coauthors, experts in the fields of molecular pathology, precision medicine, and pathology informatics, also contributed their experiences. Conclusions.--The boundary between bioinformatics and clinical informatics has significantly blurred with the introduction of NGS into clinical molecular laboratories. Next-generation sequencing technology and the data derived from these tests, if managed well in the clinical laboratory, will redefine the practice of medicine. In order to sustain this progress, adoption of smart computing technology will be essential. Computational pathologists will be expected to play a major role in rendering diagnostic and theranostic services by leveraging "Big Data" and modern computing tools. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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