Extracellular vesicles in blood, milk and body fluids of the female and male urogenital tract and with special regard to reproduction.
Extracellular vesicles (EVs) are released from almost all cells and tissues. They are able to transport substances (e.g. proteins, RNA or DNA) at higher concentrations than in their environment and may adhere in a receptor-controlled manner to specific cells or tissues in order to release their cont...
| Publicado en: | Critical Reviews in Clinical Laboratory Sciences Vol. 53; no. 6; pp. 379 - 396 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Dec2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=117923541&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 117923541 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10408363 1AV jtl: Critical Reviews in Clinical Laboratory Sciences issn: 10408363 maglogo: Y pubinfo: dt: Dec2016 vid: 53 iid: 6 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 117923541 117923541 117923541 10.1080/10408363.2016.1190682 117923541 ppf: 379 ppct: 17 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Extracellular vesicles in blood, milk and body fluids of the female and male urogenital tract and with special regard to reproduction. aug: au: Foster, B. P. Balassa, T. Benen, T. D. Dominovic, M. Elmadjian, G. K. Florova, V. Fransolet, M. D. Kestlerova, A. Kmiecik, G. Kostadinova, I. A. Kyvelidou, C. Meggyes, M. Mincheva, M. N. Moro, L. Pastuschek, J. Spoldi, V. Wandernoth, P. Weber, M. Toth, B. Markert, U. R. affil: Maternal and Fetal Health Research Centre, School of Biomedicine, University of Manchester, and Manchester Academic Health Sciences Centre, University Research, Manchester, UK sug: subj: Extracellular Space Interstitial Fluid Fluids and Secretions Exosomes Physiology Blood Milk, Human Urinary Tract Reproduction Pregnancy Female Female ab: Extracellular vesicles (EVs) are released from almost all cells and tissues. They are able to transport substances (e.g. proteins, RNA or DNA) at higher concentrations than in their environment and may adhere in a receptor-controlled manner to specific cells or tissues in order to release their content into the respective target structure. Blood contains high concentrations of EVs mainly derived from platelets, and, at a smaller amount, from erythrocytes. The female and male reproductive tracts produce EVs which may be associated with fertility or infertility and are released into body fluids and mucosas of the urogenital organs. In this review, the currently relevant detection methods are presented and critically compared. During pregnancy, placenta-derived EVs are dynamically detectable in peripheral blood with changing profiles depending upon progress of pregnancy and different pregnancy-associated pathologies, such as preeclampsia. EVs offer novel non-invasive diagnostic tools which may reflect the situation of the placenta and the foetus. EVs in urine have the potential of reflecting urogenital diseases including cancers of the neighbouring organs. Several methods for detection, quantification and phenotyping of EVs have been established, which include electron microscopy, flow cytometry, ELISA-like methods, Western blotting and analyses based on Brownian motion. This review article summarises the current knowledge about EVs in blood and cord blood, in the different compartments of the male and female reproductive tracts, in trophoblast cells from normal and pre-eclamptic pregnancies, in placenta ex vivo perfusate, in the amniotic fluid, and in breast milk, as well as their potential effects on natural killer cells as possible targets. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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