An MRI study of white matter tract integrity in regular cannabis users: effects of cannabis use and age.
Rationale: Conflicting evidence exists on the effects of cannabis use on brain white matter integrity. The extant literature has exclusively focused on younger cannabis users, with no studies sampling older cannabis users. Objectives: We recruited a sample with a broad age range to examine the integ...
| Publicado en: | Psychopharmacology Vol. 233; no. 19/20; pp. 3627 - 3638 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118059910&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118059910 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Oct2016 vid: 233 iid: 19/20 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 118059910 144057787 10.1007/s00213-016-4398-3 118059910 ppf: 3627 ppct: 11 formats: fmt: @attributes: type: P tig: atl: An MRI study of white matter tract integrity in regular cannabis users: effects of cannabis use and age. aug: au: Jakabek, David Yücel, Murat Lorenzetti, Valentina Solowij, Nadia affil: Graduate School of Medicine , University of Wollongong , Wollongong NSW 2522 Australia sug: ab: Rationale: Conflicting evidence exists on the effects of cannabis use on brain white matter integrity. The extant literature has exclusively focused on younger cannabis users, with no studies sampling older cannabis users. Objectives: We recruited a sample with a broad age range to examine the integrity of major white matter tracts in association with cannabis use parameters and neurodevelopmental stage. Methods: Regular cannabis users ( n = 56) and non-users ( n = 20) with a mean age of 32 (range 18-55 years) underwent structural and diffusion MRI scans. White matter was examined using voxel-based statistics and via probabilistic tract reconstruction. The integrity of tracts was assessed using average fractional anisotropy, axial diffusivity and radial diffusivity. Diffusion measures were compared between users and non-users and as group-by-age interactions. Correlations between diffusion measures and age of onset, duration, frequency and dose of current cannabis use were examined. Results: Cannabis users overall had lower fractional anisotropy than healthy non-users in the forceps minor tract only ( p = .015, partial eta = 0.07), with no voxel-wise differences observed. Younger users showed predominantly reduced axial diffusivity, whereas older users had higher radial diffusivity in widespread tracts. Higher axial diffusivity was associated with duration of cannabis use in the cingulum angular bundle (beta = 5.00 × 10, p = .003). Isolated higher AD in older cannabis users was also observed. Conclusions: The findings suggest that exogenous cannabinoids alter normal brain maturation, with differing effects at various neurodevelopmental stages of life. These age-related differences are posited to account for the disparate results described in the literature. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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