Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats.
Rationale: The appetite-stimulating properties of cannabis are well documented and have been predominantly attributed to the hyperphagic activity of the psychoactive phytocannabinoid, ∆-tetrahydrocannabinol (∆-THC). However, we have previously shown that a cannabis extract devoid of ∆-THC still stim...
| Publicado en: | Psychopharmacology Vol. 233; no. 19/20; pp. 3603 - 3614 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118059911&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118059911 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Oct2016 vid: 233 iid: 19/20 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 118059911 144027896 10.1007/s00213-016-4397-4 118059911 ppf: 3603 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats. aug: au: Brierley, Daniel Samuels, James Duncan, Marnie Whalley, Benjamin Williams, Claire affil: School of Psychology and Clinical Language Sciences , University of Reading , Reading UK sug: ab: Rationale: The appetite-stimulating properties of cannabis are well documented and have been predominantly attributed to the hyperphagic activity of the psychoactive phytocannabinoid, ∆-tetrahydrocannabinol (∆-THC). However, we have previously shown that a cannabis extract devoid of ∆-THC still stimulates appetite, indicating that other phytocannabinoids also elicit hyperphagia. One possible candidate is the non-psychoactive phytocannabinoid cannabigerol (CBG), which has affinity for several molecular targets with known involvement in the regulation of feeding behaviour. Objectives: The objective of the study was to assess the effects of CBG on food intake and feeding pattern microstructure. Methods: Male Lister hooded rats were administered CBG (30-120 mg/kg, per ora (p.o.)) or placebo and assessed in open field, static beam and grip strength tests to determine a neuromotor tolerability profile for this cannabinoid. Subsequently, CBG (at 30-240 mg/kg, p.o.) or placebo was administered to a further group of pre-satiated rats, and hourly intake and meal pattern data were recorded over 2 h. Results: CBG produced no adverse effects on any parameter in the neuromotor tolerability test battery. In the feeding assay, 120-240 mg/kg CBG more than doubled total food intake and increased the number of meals consumed, and at 240 mg/kg reduced latency to feed. However, the sizes or durations of individual meals were not significantly increased. Conclusions: Here, we demonstrate for the first time that CBG elicits hyperphagia, by reducing latency to feed and increasing meal frequency, without producing negative neuromotor side effects. Investigation of the therapeutic potential of CBG for conditions such as cachexia and other disorders of eating and body weight regulation is thus warranted. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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