Amide Proton Transfer (APT) MR imaging and Magnetization Transfer (MT) MR imaging of pediatric brain development.
Objectives: To quantify the brain maturation process during childhood using combined amide proton transfer (APT) and conventional magnetization transfer (MT) imaging at 3 Tesla.Methods: Eighty-two neurodevelopmentally normal children (44 males and 38 females; age range, 2-190 months) were imaged usi...
| Publicado en: | European Radiology Vol. 26; no. 10; pp. 3368 - 3377 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2016
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118060275&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118060275 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Oct2016 vid: 26 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 118060275 118060275 NLM26762941 10.1007/s00330-015-4188-z NLM26762941 118060275 ppf: 3368 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Amide Proton Transfer (APT) MR imaging and Magnetization Transfer (MT) MR imaging of pediatric brain development. aug: au: Zhang, Hong Kang, Huiying Zhao, Xuna Jiang, Shanshan Zhang, Yi Zhou, Jinyuan Peng, Yun affil: Imaging Center, Department of Radiology , Beijing Children's Hospital, Capital Medical University , Beijing China sug: subj: Amides Magnetic Resonance Imaging Methods Protons Brain Telencephalon Reference Values Infant Child, Preschool Male Female Child Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Male Female ab: Objectives: To quantify the brain maturation process during childhood using combined amide proton transfer (APT) and conventional magnetization transfer (MT) imaging at 3 Tesla.Methods: Eighty-two neurodevelopmentally normal children (44 males and 38 females; age range, 2-190 months) were imaged using an APT/MT imaging protocol with multiple saturation frequency offsets. The APT-weighted (APTW) and MT ratio (MTR) signals were quantitatively analyzed in multiple brain areas. Age-related changes in MTR and APTW were evaluated with a non-linear regression analysis.Results: The APTW signals followed a decreasing exponential curve with age in all brain regions measured (R(2) = 0.7-0.8 for the corpus callosum, frontal and occipital white matter, and centrum semiovale). The most significant changes appeared within the first year. At maturation, larger decreases in APTW and lower APTW values were found in the white matter. On the contrary, the MTR signals followed an increasing exponential curve with age in the same brain regions measured, with the most significant changes appearing within the initial 2 years. There was an inverse correlation between the MTR and APTW signal intensities during brain maturation.Conclusions: Together with MT imaging, protein-based APT imaging can provide additional information in assessing brain myelination in the paediatric population.Key Points: • APTW signals followed a decreasing exponential curve with age. • The most significant APTW changes appeared within the first year • At maturation, larger APTW decreases and lower APTW appeared in white matter • MTR signals followed an increasing exponential curve with age. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|