Abnormal auditory pattern perception in schizophrenia.
Mismatch negativity (MMN) in response to deviation from physical sound parameters (e.g., pitch, duration) is reduced in individuals with long-term schizophrenia (Sz), suggesting deficits in deviance detection. However, MMN can appear at several time intervals as part of deviance detection. Understan...
| Publicado en: | Schizophrenia Research Vol. 176; no. 2/3; pp. 473 - 480 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Oct2016
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118101427&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118101427 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09209964 3PT jtl: Schizophrenia Research issn: 09209964 maglogo: N pubinfo: dt: Oct2016 vid: 176 iid: 2/3 pid: 1004 pub: Elsevier B.V. artinfo: ui: 118101427 118101427 NLM27502427 118101427 10.1016/j.schres.2016.07.007 NLM27502427 PMC5026944 [Available on 10/01/17] 118101427 ppf: 473 ppct: 7 formats: tig: atl: Abnormal auditory pattern perception in schizophrenia. aug: au: Haigh, Sarah M. Coffman, Brian A. Murphy, Timothy K. Butera, Christiana D. Salisbury, Dean F. affil: Department of Psychiatry, University of Pittsburgh School of Medicine, 3501 Forbes Avenue, Pittsburgh, PA 15213, United States sug: subj: Psychotic Disorders Physiopathology Brain Physiopathology Auditory Perception Physiology Schizophrenia Physiopathology Evoked Potentials, Auditory Adult Female Neuropsychological Tests Diagnosis, Psychosocial Male Electroencephalography Psychological Tests Acoustic Stimulation Funding Source Human Adult: 19-44 years Female Male ab: Mismatch negativity (MMN) in response to deviation from physical sound parameters (e.g., pitch, duration) is reduced in individuals with long-term schizophrenia (Sz), suggesting deficits in deviance detection. However, MMN can appear at several time intervals as part of deviance detection. Understanding which part of the processing stream is abnormal in Sz is crucial for understanding MMN pathophysiology. We measured MMN to complex pattern deviants, which have been shown to produce multiple MMNs in healthy controls (HC). Both simple and complex MMNs were recorded from 27 Sz and 27 matched HC. For simple MMN, pitch- and duration-deviants were presented among frequent standard tones. For complex MMN, patterns of five single tones were repeatedly presented, with the occasional deviant group of tones containing an extra sixth tone. Sz showed smaller pitch MMN (p=0.009, ~110ms) and duration MMN (p=0.030, ~170ms) than healthy controls. For complex MMN, there were two deviance-related negativities. The first (~150ms) was not significantly different between HC and SZ. The second was significantly reduced in Sz (p=0.011, ~400ms). The topography of the late complex MMN was consistent with generators in anterior temporal cortex. Worse late MMN in Sz was associated with increased emotional withdrawal, poor attention, lack of spontaneity/conversation, and increased preoccupation. Late MMN blunting in schizophrenia suggests a deficit in later stages of deviance processing. Correlations with negative symptoms measures are preliminary, but suggest that abnormal complex auditory perceptual processes may compound higher-order cognitive and social deficits in the disorder. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|