Association between genetic risk score for telomere length and risk of breast cancer.
Purpose: While leukocyte telomere length (TL) has been associated with breast cancer risk, limited information is available regarding the role of genetically-determined TL on breast cancer risk. We investigated whether aggregated TL-associated variants are associated with the risk of breast cancer i...
| Publicado en: | Cancer Causes & Control Vol. 27; no. 10; pp. 1219 - 1229 |
|---|---|
| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2016
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118120759&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118120759 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09575243 ODX jtl: Cancer Causes & Control issn: 09575243 maglogo: N pubinfo: dt: Oct2016 vid: 27 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 118120759 118120759 143966811 NLM27581250 118120759 10.1007/s10552-016-0800-z NLM27581250 118120759 ppf: 1219 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Association between genetic risk score for telomere length and risk of breast cancer. aug: au: Luu, Hung Long, Jirong Wen, Wanqing Zheng, Ying Cai, Qiuyin Gao, Yu-Tang Zheng, Wei Shu, Xiao-Ou Luu, Hung N affil: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center , Vanderbilt University School of Medicine , 2525 West End Avenue, Suite 600 (IMPH) Nashville 37203-1738 USA sug: subj: Telomere Breast Neoplasms White Persons Statistics and Numerical Data Ethnic Groups China Asians Genetics Asians Statistics and Numerical Data Polymorphism, Genetic Breast Neoplasms Epidemiology Adult Middle Age Alleles White Persons Female Case Control Studies Disease Susceptibility Sequence Analysis Funding Source Human Adult: 19-44 years Middle Aged: 45-64 years Female ab: Purpose: While leukocyte telomere length (TL) has been associated with breast cancer risk, limited information is available regarding the role of genetically-determined TL on breast cancer risk. We investigated whether aggregated TL-associated variants are associated with the risk of breast cancer in 2,865 breast cancer cases and 2,285 controls from the Shanghai Breast Cancer Genetics Study.Methods: Six genetic variants, identified through a genome-wide association study (GWAS) of TL in European-ancestry participants, were included in the study. A separate sample [n = 1,536, from the Shanghai Women's Health Study (SWHS), for whom information on both phenotypical leukocyte TL and genetic information was collected] was used to evaluate the association of six variants with TL in Asians. Three genetic risk scores (GRSs), based on the number of alleles associated with shorter TL that each individual carries for the six variants, were derived for the study: un-weighted, internally weighted (from the SWHS), and externally weighted (from the European-ancestry GWAS study), and evaluated for their association with breast cancer risk by applying logistic regression analysis.Results: Both internally and externally weighted GRSs were significantly associated with a decreased risk of breast cancer (OR 0.83, 95 % CI 0.72-0.95 and OR 0.84, 95 % CI 0.74-0.96, respectively, for tertile 3 vs. tertile 1). Non-genetic risk factors for breast cancer (i.e., age, years of menstruation/reproduction, oral contraceptive usage, and BMI) did not modify the association between GRSs and the risk of breast cancer.Conclusion: Our results suggest that short TL, determined by genetic factors, may be associated with a reduced susceptibility to breast cancer. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|