Risks of Death and Severe Disease in Patients With Middle East Respiratory Syndrome Coronavirus, 2012-2015.
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging pathogen, first recognized in 2012, with a high case fatality risk, no vaccine, and no treatment beyond supportive care. We estimated the relative risks of death and severe disease among MERS-CoV patients in the Middle East betwe...
| Publicado en: | American Journal of Epidemiology Vol. 184; no. 6; pp. 460 - 465 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
9/15/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118129650&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118129650 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00029262 1X1 jtl: American Journal of Epidemiology issn: 00029262 maglogo: N pubinfo: dt: 9/15/2016 vid: 184 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 118129650 118129650 118129650 10.1093/aje/kww013 118129650 ppf: 460 ppct: 5 formats: tig: atl: Risks of Death and Severe Disease in Patients With Middle East Respiratory Syndrome Coronavirus, 2012-2015. aug: au: Rivers, Caitlin M. Majumder, Maimuna S. Lofgren, Eric T. affil: Network Dynamics and Simulation Science Laboratory, Biocomplexity Institute of Virginia Tech, Virginia Polytechnic Institute and State University, Blacksburg, Virginia sug: subj: Middle East Respiratory Syndrome Coronavirus Mortality Risk Factors Epidemiology Coronavirus Infections Risk Factors Human Male Female Regression Poisson Distribution Age Factors Comorbidity Algorithms Social Determinants of Health Health Status Disparities Severity of Illness Descriptive Statistics Confidence Intervals Data Analysis Software P-Value Record Review Adult Middle Age Aged Age of Onset Funding Source Coronavirus Infections Prognosis Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging pathogen, first recognized in 2012, with a high case fatality risk, no vaccine, and no treatment beyond supportive care. We estimated the relative risks of death and severe disease among MERS-CoV patients in the Middle East between 2012 and 2015 for several risk factors, using Poisson regression with robust variance and a bootstrap-based expectation maximization algorithm to handle extensive missing data. Increased age and underlying comorbidity were risk factors for both death and severe disease, while cases arising in Saudi Arabia were more likely to be severe. Cases occurring later in the emergence of MERS-CoV and among health-care workers were less serious. This study represents an attempt to estimate risk factors for an emerging infectious disease using open data and to address some of the uncertainty surrounding MERS-CoV epidemiology. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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