Response Surface Analysis and Nonlinear Optimization Algorithm for Maximization of Clinical Drug Performance: Application to Extended-Release and Long-Acting Injectable Paliperidone.
Model-based approach is recognized as a tool to make drug development more productive and to better support regulatory and therapeutic decisions. The objective of this study was to develop a novel model-based methodology based on the response surface analysis and a nonlinear optimizer algorithm to m...
| Published in: | Journal of Clinical Pharmacology Vol. 56; no. 10; pp. 1296 - 1307 |
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| Main Authors: | , , |
| Format: | case study equations & formulas research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Oct2016
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| Online Access: | View this record in EBSCOhost |