Kinetic DTI of the cervical spine: diffusivity changes in healthy subjects.
Introduction: The study aims to assess the influence of neck extension on water diffusivity within the cervical spinal cord. Methods: IRB approved the study in 22 healthy volunteers. All subjects underwent anatomical MR and diffusion tensor imaging (DTI) at 1.5 T. The cervical cord was imaged in neu...
| Publicado en: | Neuroradiology Vol. 58; no. 9; pp. 929 - 936 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118280606&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118280606 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Sep2016 vid: 58 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 118280606 118280606 118280606 10.1007/s00234-016-1709-7 118280606 ppf: 929 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Kinetic DTI of the cervical spine: diffusivity changes in healthy subjects. aug: au: Kuhn, Félix Feydy, Antoine Launay, Nathalie Lefevre-Colau, Marie-Martine Poiraudeau, Serge Laporte, Sébastien Maier, Marc Lindberg, Pavel affil: Service de Radiologie B, APHP, Centre Hospitalier Universitaire Cochin, Faculté de Médecine , Université Paris Descartes , 27 rue du Fbg St Jacques 75679 Paris France sug: subj: Cervical Vertebrae Physiology Kinetics Cervical Cord Radiography Magnetic Resonance Imaging Methods Biomechanics Human Extension Software Rotation Intrarater Reliability Descriptive Statistics Neck Anatomy and Histology Water ab: Introduction: The study aims to assess the influence of neck extension on water diffusivity within the cervical spinal cord. Methods: IRB approved the study in 22 healthy volunteers. All subjects underwent anatomical MR and diffusion tensor imaging (DTI) at 1.5 T. The cervical cord was imaged in neutral (standard) position and extension. Segmental vertebral rotations were analyzed on sagittal T2-weighted images using the SpineView® software. Spinal cord diffusivity was measured in cross-sectional regions of interests at multiple levels (C1-C5). Results: As a result of non-adapted coil geometry for spinal extension, 10 subjects had to be excluded. Image quality of the remaining 12 subjects was good without any deteriorating artifacts. Quantitative measurements of vertebral rotation angles and diffusion parameters showed good intra-rater reliability (ICC = 0.84-0.99). DTI during neck extension revealed significantly decreased fractional anisotropy (FA) and increased radial diffusivity (RD) at the C3 level and increased apparent diffusion coefficients (ADC) at the C3 and C4 levels ( p < 0.01 Bonferroni corrected). The C3/C4 level corresponded to the maximal absolute change in segmental vertebral rotation between the two positions. The increase in RD correlated positively with the degree of global extension, i.e., the summed vertebral rotation angle between C1 and C5 ( R = 0.77, p = 0.006). Conclusion: Our preliminary results suggest that DTI can quantify changes in water diffusivity during cervical spine extension. The maximal differences in segmental vertebral rotation corresponded to the levels with significant changes in diffusivity (C3/C4). Consequently, kinetic DTI measurements may open new perspectives in the assessment of neural tissue under biomechanical constraints. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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