The incidence of gastrointestinal pathology and subsequent anemia in young men presenting with iron deficiency without anemia.
Background and Aims: The etiology of iron deficiency (ID) without anemia in young men is unclear, and there are no evidence-based recommendations for the required gastrointestinal (GI) evaluation. The aims of this study were to examine the incidence of significant GI pathology and the development of...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 28; no. 10; pp. 1126 - 1130 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Oct2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118301571&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118301571 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: Oct2016 vid: 28 iid: 10 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 118301571 118301571 NLM27337098 118301571 10.1097/MEG.0000000000000687 NLM27337098 118301571 ppf: 1126 ppct: 4 formats: tig: atl: The incidence of gastrointestinal pathology and subsequent anemia in young men presenting with iron deficiency without anemia. aug: au: Carter, Dan Bardan, Eytan Derazne, Estela Tzur, Dorit Avidan, Benjamin affil: Medical Corps, Israel Defense Forces, Tel Hasomher sug: subj: Gastrointestinal System Pathology Iron Metabolism Disorders Epidemiology Anemia, Iron Deficiency Epidemiology Gastrointestinal Diseases Epidemiology Iron Deficiency Risk Factors Disease Progression Time Factors Adult Prospective Studies Iron Blood Iron Metabolism Disorders Diagnosis Young Adult Adolescence Anemia, Iron Deficiency Blood Gastrointestinal Diseases Diagnosis Israel Incidence Iron Metabolism Disorders Blood Odds Ratio Anemia, Iron Deficiency Diagnosis Gastrointestinal Diseases Pathology Male Human Adult: 19-44 years Adolescent: 13-18 years Male ab: Background and Aims: The etiology of iron deficiency (ID) without anemia in young men is unclear, and there are no evidence-based recommendations for the required gastrointestinal (GI) evaluation. The aims of this study were to examine the incidence of significant GI pathology and the development of anemia during the follow-up of young men presenting with ID, but without anemia.Methods: All young men (18-30 years) who served in the Israel Defense Forces during the years 2005-2013 and had at least a single laboratory test indicative of ID without anemia were followed until the diagnosis of significant GI pathology or discharge from military service.Results: The study population included 2061 young men (mean age 20.7±1.8). During follow-up of 3150 person years, significant GI pathologies were diagnosed in 39 patients: inflammatory bowel disease in 25 (1.2%), celiac disease in 8 (0.4%), and peptic disease in 4 (0.1%). No cases of GI-related cancer were diagnosed. ID anemia developed during follow-up in 203 (9.8%). Lower baseline hemoglobin levels, lower ferritin levels, and younger age at diagnosis were more common among those who developed anemia. The development of anemia was a predisposing factor for the diagnosis of GI pathology (risk ratio=3.60, 95% confidence interval 1.34-8.32, P=0.012).Conclusion: Significant GI pathology is very uncommon in young men presenting with ID. Overt anemia developed in close to 10% of the study cohort. Therefore, we advise simple GI evaluation (celiac serology, C-reactive protein or fecal calprotectin, and urease breath test) as well as follow-up in this population. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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