Interferon α kinoid induces neutralizing anti-interferon α antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon α kinoid phase I/II study.

Objective. IFN α Kinoid (IFN-K) is a therapeutic vaccine composed of IFNα2b coupled to a carrier protein. In a phase I/II placebo-controlled trial, we observed that IFN-K significantly decreases the IFN gene signature in whole blood RNA samples from SLE patients. Here, we analysed extended follow-up...

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Bibliographic Details

Published in:	Rheumatology Vol. 55; no. 10; pp. 1901 - 1906
Main Authors:	Ducreux, Julie, Houssiau, Frédéric A., Vandepapelière, Pierre, Jorgensen, Christian, Lazaro, Estibaliz, Spertini, François, Colaone, Fabien, Roucairol, Camille, Laborie, Marion, Croughs, Thérèse, Grouard-Vogel, Géraldine, Lauwerys, Bernard R.
Format:	pictorial research tables/charts randomized controlled trial Journal Article
Published:	Oxford University Press / USA Oct2016
Online Access:	View this record in EBSCOhost