Rearing environment differentially modulates cocaine self-administration after opioid pretreatment: A behavioral economic analysis.
Background: Research has shown that previous experiences during development, especially if stressful, can alter an organism's response to opioids later in life. Given the previous literature on opioid modulation of cocaine self-administration, the current study raised rats in either an enriched cond...
| Published in: | Drug & Alcohol Dependence Vol. 167; pp. 89 - 95 |
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| Main Authors: | , , |
| Format: | research Journal Article |
| Published: |
Elsevier B.V.
Oct2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118312096&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118312096 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03768716 3S6 jtl: Drug & Alcohol Dependence issn: 03768716 maglogo: N pubinfo: dt: Oct2016 vid: 167 pid: 1004 pub: Elsevier B.V. artinfo: ui: 118312096 118312096 NLM27511893 118312096 10.1016/j.drugalcdep.2016.07.026 NLM27511893 PMC5037017 [Available on 10/01/17] 118312096 ppf: 89 ppct: 6 formats: tig: atl: Rearing environment differentially modulates cocaine self-administration after opioid pretreatment: A behavioral economic analysis. aug: au: Hofford, Rebecca S. Beckmann, Joshua S. Bardo, Michael T. affil: Department of Psychology, University of Kentucky, United States sug: subj: Analgesics, Opioid Pharmacodynamics Morphine Pharmacodynamics Behavior, Animal Drug Effects Cocaine Administration and Dosage Naltrexone Pharmacodynamics Narcotic Antagonists Pharmacodynamics Rats Environment Animal Studies Substance Use Disorders Psychosocial Factors Self Administration Time Factors ab: Background: Research has shown that previous experiences during development, especially if stressful, can alter an organism's response to opioids later in life. Given the previous literature on opioid modulation of cocaine self-administration, the current study raised rats in either an enriched condition (EC) or isolated condition (IC) and employed behavioral economics to study the effects of naltrexone and morphine on cocaine self-administration.Methods: EC and IC rats were trained to lever press for cocaine using a within-session demand procedure. This procedure measured cocaine consumption under changing cocaine price by decreasing the dose of cocaine earned throughout a session. Rats were able to self-administer cocaine on a FR1; every 10min the cocaine dose was systematically decreased (0.75-0.003mg/kg/infusion cocaine). After reaching stability on this procedure, rats were randomly pretreated with 0, 0.3, 1, or 3mg/kg naltrexone once every 3days, followed by random pretreatments of 0, 0.3, 1, or 3mg/kg morphine once every 3days. Economic demand functions were fit to each rat's cocaine consumption from each pretreatment, and appropriate mathematical parameters were extracted and analyzed.Results: Naltrexone decreased the essential value of cocaine in IC rats only. However, morphine decreased the essential value of cocaine and the consumption of cocaine at zero price in both EC and IC rats.Conclusion: These results indicate that environmental experiences during development should be considered when determining the efficacy of opioid drugs, especially for the treatment of substance abuse. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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