Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study.
The objective of this randomized, open-label, single-dose, two-phase crossover study was to determine the effect of ascorbic acid on pharmacokinetics of ganoderic acid A, an important biologically active triterpenoid compound with anticancer activities, following oral administration of water extract...
| Published in: | BioMed Research International Vol. 2016; pp. 1 - 8 |
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| Main Authors: | , , , , |
| Format: | research tables/charts randomized controlled trial Journal Article |
| Published: |
Wiley-Blackwell
9/25/2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118314040&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118314040 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 9/25/2016 vid: 2016 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 118314040 118314040 118314040 10.1155/2016/2819862 118314040 ppf: 1 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study. aug: au: Tawasri, Patcharanee Ampasavate, Chadarat Tharatha, Somsak Chiranthanut, Natthakarn Teekachunhatean, Supanimit affil: Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand sug: subj: Ascorbic Acid Administration and Dosage Terpenes Pharmacokinetics Plant Extracts Administration and Dosage Terpenes Administration and Dosage Drug Therapy, Combination Mushroom, Edible Antineoplastic Agents Administration and Dosage Antineoplastic Agents Analysis Human Male Randomized Controlled Trials Crossover Design Terpenes Blood Chromatography, Liquid Methods Mass Spectrometry Methods Adolescence Adult Biological Availability Drug Synergism P-Value Correlation Coefficient Biological Assay Descriptive Statistics Wilcoxon Signed Rank Test Thailand Funding Source Data Analysis Software Adolescent: 13-18 years Adult: 19-44 years Male ab: The objective of this randomized, open-label, single-dose, two-phase crossover study was to determine the effect of ascorbic acid on pharmacokinetics of ganoderic acid A, an important biologically active triterpenoid compound with anticancer activities, following oral administration of water extract of fruiting bodies of Ling Zhi in 12 healthy male subjects. Each subject was randomized to receive either one of the two regimens: (1) a single dose of 3,000 mg of the Ling Zhi preparation or (2) a single dose of 3,000 mg of the Ling Zhi preparation in combination with 2,500 mg of ascorbic acid. After a washout period of at least two weeks, subjects were switched to receive the alternate regimen. Blood samples were collected in each phase immediately before dosing and at specific time points for 8 hours after dosing. Plasma ganoderic acid A concentrations were quantified using liquid chromatography-mass spectrometry (LC-MS). The pharmacokinetic parameters analyzed were maximal plasma concentration (Cmax), time to reach peak concentration (Tmax), area under the plasma concentration-time curve (AUC), and half-life (t1/2). An oral coadministration of ascorbic acid with Ling Zhi preparation did not significantly alter the pharmacokinetic parameters of ganoderic acid A in healthy male subjects. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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