A multifunctional diet improves cardiometabolic-related biomarkers independently of weight changes: an 8-week randomized controlled intervention in healthy overweight and obese subjects.
Purpose: A multifunctional diet (MFD) was previously shown to reduce blood lipids, CRP and blood pressure in a 4-week intervention under weight-maintenance conditions. Here, MFD effects were evaluated in an 8-week intervention with no restriction for weight changes. Methods: Healthy subjects consume...
| Publicado en: | European Journal of Nutrition Vol. 55; no. 7; pp. 2295 - 2307 |
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| Autores principales: | , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Oct2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118328104&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118328104 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Oct2016 vid: 55 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 118328104 118328104 118328104 10.1007/s00394-015-1039-2 118328104 ppf: 2295 ppct: 12 formats: fmt: @attributes: type: P tig: atl: A multifunctional diet improves cardiometabolic-related biomarkers independently of weight changes: an 8-week randomized controlled intervention in healthy overweight and obese subjects. aug: au: Tovar, Juscelino Johansson, Maria Björck, Inger affil: Food for Health Science Centre , Lund University , Medicon Village 223 81 Lund Sweden sug: subj: Obesity Diet Therapy Cardiovascular Risk Factors Prevention and Control Metabolic Syndrome X Risk Factors Body Weight Changes Functional Food Human Randomized Controlled Trials Random Assignment Intervention Trials Funding Source Pretest-Posttest Design Cholesterol Blood Blood Glucose Analysis Insulin Blood Glycated Hemoglobin Blood Body Weights and Measures Blood Pressure Determination Hydrogen Analysis Breath Tests Middle Age Aged Male Female Statistical Significance Weight Loss Lipoproteins, LDL Cholesterol Blood P-Value Triglycerides Blood Lipoproteins, HDL Cholesterol Blood Apolipoproteins Blood Systolic Pressure Enzymes Blood Questionnaires Descriptive Statistics Paired T-Tests T-Tests Unpaired T-Tests Clinical Assessment Tools Data Analysis Software Power Analysis Sweden Diet Classification Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: A multifunctional diet (MFD) was previously shown to reduce blood lipids, CRP and blood pressure in a 4-week intervention under weight-maintenance conditions. Here, MFD effects were evaluated in an 8-week intervention with no restriction for weight changes. Methods: Healthy subjects consumed MFD (23 subjects) or a control diet (CD) devoid of the functional components (24 subjects) in a 'free-living' randomized controlled experiment. MFD included several functional concepts: low-glycemic-impact meals, antioxidant-rich foods, oily fish, viscous dietary fibers, soybean and whole barley kernel products, almonds and plant stanols. Measured outcomes were fasting blood values of lipids, glucose, insulin, GGT, CRP, HbA1c, PAI-1, GLP-1, GLP-2, body weight, blood pressure and breath hydrogen. Results: At baseline, participants were 51-72 years old, with BMI between 25 and 34 and fasting glycemia ≤ 6.1 mmol/L. Consumption of both diets resulted in similar weight loss after 8 weeks (−4 %; P < 0.001). Compared to baseline, consumption of MFD reduced total serum cholesterol (−26 %; P < 0.0001), LDL cholesterol (−35 %; P < 0.0001), triglycerides (−16 %; P < 0.05), LDL/HDL (−27 %; P < 0.0001) and ApoB/ApoA1 (−15 %; P < 0.0001). There were important net differences between diets, which remained significant after adjustment for body weight. Reduced systolic blood pressure, circulating GGT, HbA1c and insulin concentrations were observed with both MFD and CD with no difference between diets. The Reynolds cardiovascular risk score was decreased by 36 % ( P < 0.0001) with MFD. MFD increased breath hydrogen levels (120 %; P < 0.05). Conclusions: Consumption of MFD decreased blood lipids and improved several other aspects of the cardiometabolic risk profile. This effect was not dependent on weight loss. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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