Severity of Gastric Mucosal Atrophy Is the Major Determinant of Plasma Ghrelin Level in Hemodialysis Patients.
Background: Ghrelin, an orexigenic hormone, has multiple favorable functions including protein anabolism enhancement, anti-inflammatory actions, and cardiovascular protection. A low plasma ghrelin level is associated with increased mortality in patients treated with hemodialysis (HD). However, it is...
| Publicado en: | American Journal of Nephrology Vol. 44; no. 3; pp. 224 - 234 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Karger AG
Sep2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118350774&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118350774 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02508095 8BL jtl: American Journal of Nephrology issn: 02508095 maglogo: N pubinfo: dt: Sep2016 vid: 44 iid: 3 pid: 2485 pub: Karger AG artinfo: ui: 118350774 118350774 NLM27578611 118350774 10.1159/000449019 NLM27578611 118350774 ppf: 224 ppct: 10 formats: tig: atl: Severity of Gastric Mucosal Atrophy Is the Major Determinant of Plasma Ghrelin Level in Hemodialysis Patients. aug: au: Sakao, Yukitoshi Sugimoto, Mitsushige Ichikawa, Hitomi Sahara, Shu Tsuji, Takayuki Ohashi, Naro Kato, akihiko Fujigaki, Yoshihide Sugimoto, Ken Furuta, Takahisa Sakao, Tadashi Yasuda, Hideo affil: Hamana Clinic, Hamamatsu sug: subj: Helicobacter Infections Blood Gastric Mucosa Pathology Renal Insufficiency, Chronic Therapy Ghrelin Blood Helicobacter Pylori Atrophy Blood Aged, 80 and Over Helicobacter Infections Complications Middle Age Creatinine Blood Breath Tests Renal Insufficiency, Chronic Complications Renal Insufficiency, Chronic Blood Serum Albumin Metabolism Atrophy Microbiology Enzymes Blood Hemodialysis Atrophy Gastroscopy Aged Severity of Illness Indices Helicobacter Infections Diagnosis Age Factors Human Aged, 80 & over Middle Aged: 45-64 years Aged: 65+ years ab: Background: Ghrelin, an orexigenic hormone, has multiple favorable functions including protein anabolism enhancement, anti-inflammatory actions, and cardiovascular protection. A low plasma ghrelin level is associated with increased mortality in patients treated with hemodialysis (HD). However, it is unclear whether the plasma ghrelin level in HD patients correlates with the severity of gastric mucosal atrophy and Helicobacter pylori status.Methods: Seventy-eight maintenance HD patients and 51 non-dialysis patients with chronic kidney disease were evaluated for severity of gastric mucosal atrophy by gastroduodenoscopy and for H. pylori status using an anti-H. pylori-antibody and rapid urease test. Plasma acyl and des-acyl ghrelin levels were measured and their associations with relevant clinical parameters were investigated.Results: Des-acyl ghrelin level in HD patients was significantly higher than that in patients with kidney function preserved. Although acyl and des-acyl ghrelin levels were similar between current H. pylori positive and negative HD patients, both levels decreased significantly with the progress of endoscopic gastric mucosal atrophy in HD patients. Serum pepsinogen (PG) I level and PG I/II ratio decreased significantly according to the severity of atrophy in HD patients and positively significantly correlated with both ghrelin levels. Multiple regression analysis showed significant positive correlations between acyl ghrelin and PG I levels (β = 0.738, p < 0.001) and significant negative correlations between ghrelin and age, albumin, and creatinine levels.Conclusions: Gastric atrophy is the major determinant of ghrelin level in HD patients. Management practices, such as H. pylori eradication, before advanced atrophy may be required to prevent the decrease of ghrelin levels and improve the prognosis of HD patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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