ACE inhibition modifies exercise-induced pro-angiogenic and mitochondrial gene transcript expression.
Skeletal muscle responds to endurance exercise with an improvement of biochemical pathways that support substrate supply and oxygen-dependent metabolism. This is reflected by enhanced expression of associated factors after exercise and is specifically modulated by tissue perfusion and oxygenation. W...
| Publicado en: | Scandinavian Journal of Medicine & Science in Sports (John Wiley & Sons, Inc.) Vol. 26; no. 10; pp. 1180 - 1188 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
John Wiley & Sons, Inc.
Oct2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118370254&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118370254 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16000838 NRNW jtl: Scandinavian Journal of Medicine & Science in Sports (John Wiley & Sons, Inc.) issn: 16000838 maglogo: N pubinfo: dt: Oct2016 vid: 26 iid: 10 pid: 52269 pub: John Wiley & Sons, Inc. artinfo: ui: 118370254 118370254 118370254 10.1111/sms.12572 118370254 ppf: 1180 ppct: 8 formats: tig: atl: ACE inhibition modifies exercise-induced pro-angiogenic and mitochondrial gene transcript expression. aug: au: Ginkel, S. Ruoss, S. Valdivieso, P. Degens, H. Waldron, S. Haan, A. Flück, M. affil: School of Healthcare Science, Manchester Metropolitan University, Manchester UK sug: subj: Gene Expression Angiotensin-Converting Enzyme Inhibitors Therapeutic Use Exercise Physiology Muscle, Skeletal Metabolism Transcription Factors Adaptation, Physiological Vasoconstriction Biopsy Vascular Endothelial Growth Factors Cycling Blood Pressure Aerobic Capacity Exercise Test Prospective Studies Data Analysis Software Paired T-Tests Analysis of Variance P-Value Clinical Assessment Tools Adult Male Human Adult: 19-44 years Male ab: Skeletal muscle responds to endurance exercise with an improvement of biochemical pathways that support substrate supply and oxygen-dependent metabolism. This is reflected by enhanced expression of associated factors after exercise and is specifically modulated by tissue perfusion and oxygenation. We hypothesized that transcript expression of pro-angiogenic factors ( VEGF, tenascin- C, Angpt1, Angpt1 R) and oxygen metabolism ( COX4I1, COX4I2, HIF-1α) in human muscle after an endurance stimulus depends on vasoconstriction, and would be modulated through angiotensin-converting enzyme inhibition by intake of lisinopril. Fourteen non-specifically trained, male Caucasians subjects, carried out a single bout of standardized one-legged bicycle exercise. Seven of the participants consumed lisinopril in the 3 days before exercise. Biopsies were collected pre- and 3 h post-exercise from the m. vastus lateralis. COX4I1 ( P = 0.03), COX4I2 ( P = 0.04) m RNA and HIF-1α ( P = 0.05) m RNA and protein levels ( P = 0.01) showed an exercise-induced increase in the group not consuming the ACE inhibitor. Conversely, there was a specific exercise-induced increase in VEGF transcript ( P = 0.04) and protein levels ( P = 0.03) and a trend for increased tenascin-c transcript levels ( P = 0.09) for subjects consuming lisinopril. The observations indicate that exercise-induced expression of transcripts involved in angiogenesis and mitochondrial energy metabolism are to some extent regulated via a hypoxia-related ACE-dependent mechanism. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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