The Role of the Insular Cortex in Naloxone-Induced Conditioned Place Aversion in Morphine-Dependent Mice.
A negative emotional state resulting from the withdrawal of drug addiction is thought to be an important factor that triggers and exacerbates relapse. Since the insular cortex is a key brain structure involved in the modulation of negative emotions, we investigated whether the integrity of the insul...
| Publicado en: | Physiological Research Vol. 65; no. 4; pp. 701 - 710 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
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Institute of Physiology, Academy of Sciences of the Czech Republic
2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118409003&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118409003 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08628408 1CVW jtl: Physiological Research issn: 08628408 maglogo: N pubinfo: dt: 2016 vid: 65 iid: 4 pid: 24634 pub: Institute of Physiology, Academy of Sciences of the Czech Republic artinfo: ui: 118409003 10.33549/physiolres.933106 118409003 ppf: 701 ppct: 9 formats: fmt: @attributes: type: P tig: atl: The Role of the Insular Cortex in Naloxone-Induced Conditioned Place Aversion in Morphine-Dependent Mice. aug: au: Fang WANG Xiaolong JING Jingyu YANG Huan WANG Rongwu XIANG Wenyan HAN Xinxin LIU Chunfu WU affil: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China sug: ab: A negative emotional state resulting from the withdrawal of drug addiction is thought to be an important factor that triggers and exacerbates relapse. Since the insular cortex is a key brain structure involved in the modulation of negative emotions, we investigated whether the integrity of the insular cortex was important for motivational aversion associated with morphine withdrawal as well as whether this kind of negative emotion induced neuroadaptation in the insular cortex. In this present study, a sensitive mouse conditioned place aversion (CPA) model measuring the motivational aversion of morphine withdrawal was first established. Our results showed that bilateral insular cortex lesions by kainic acid completely inhibited the expression of CPA. The expression of FosB/ΔFosB in the insular cortex was significantly increased 24 h after the CPA regime was performed, but the expression of c-Fos in the insular cortex did not changed. These findings indicate that the integrity of the insular cortex is essential to motivational aversion associated with morphine withdrawal, and that this kind of aversion induces neuroadaptation, observed as the increase of FosB/ΔFosB expression, in the insular cortex. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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