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Identification of a candidate biomarker from perfusion MRI to anticipate glioblastoma progression after chemoradiation.

Objective: To identify relevant relative cerebral blood volume biomarkers from T2* dynamic-susceptibility contrast magnetic resonance imaging to anticipate glioblastoma progression after chemoradiation.Methods: Twenty-five patients from a prospective study with glioblastoma, primarily treated by che...

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Published in:European Radiology Vol. 26; no. 11; pp. 4194 - 4204
Main Authors: Khalifa, J., Tensaouti, F., Chaltiel, L., Lotterie, J.-A., Catalaa, I., Sunyach, M., Ibarrola, D., Noël, G., Truc, G., Walker, P., Magné, N., Charissoux, M., Ken, S., Peran, P., Berry, I., Moyal, E., Laprie, A., Sunyach, M P, Moyal, E Cohen-Jonathan
Format: diagnostic images research tables/charts randomized controlled trial Journal Article
Published: Springer Nature Nov2016
Online Access:View this record in EBSCOhost
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      dt: Nov2016
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      pub: Springer Nature
      place: New York, New York
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        atl: Identification of a candidate biomarker from perfusion MRI to anticipate glioblastoma progression after chemoradiation.
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        au:
          Khalifa, J.
          Tensaouti, F.
          Chaltiel, L.
          Lotterie, J.-A.
          Catalaa, I.
          Sunyach, M.
          Ibarrola, D.
          Noël, G.
          Truc, G.
          Walker, P.
          Magné, N.
          Charissoux, M.
          Ken, S.
          Peran, P.
          Berry, I.
          Moyal, E.
          Laprie, A.
          Sunyach, M P
          Moyal, E Cohen-Jonathan
        affil: INSERM UMR 1214, TONIC (TOulouse NeuroImaging Centre) , 31059 Toulouse France
      sug:
        subj:
          Brain Neoplasms Therapy
          Glioma Therapy
          Contrast Media
          Brain Neoplasms Pathology
          Middle Age
          Neoplasm Recurrence, Local Pathology
          Glioma Physiopathology
          Glioma Pathology
          Female
          Human
          Disease Progression
          Male
          Brain Neoplasms Physiopathology
          Aged
          Adult
          ROC Curve
          Magnetic Resonance Imaging Methods
          Prospective Studies
          Blood Volume
          Clinical Trials
          Validation Studies
          Comparative Studies
          Evaluation Research
          Multicenter Studies
          Randomized Controlled Trials
          Random Assignment
          Middle Aged: 45-64 years
          Aged: 65+ years
          Adult: 19-44 years
          Female
          Male
      ab: Objective: To identify relevant relative cerebral blood volume biomarkers from T2* dynamic-susceptibility contrast magnetic resonance imaging to anticipate glioblastoma progression after chemoradiation.Methods: Twenty-five patients from a prospective study with glioblastoma, primarily treated by chemoradiation, were included. According to the last follow-up MRI confirmed status, patients were divided into: relapse group (n = 13) and control group (n = 12). The time of last MR acquisition was tend; MR acquisitions performed at tend-2M, tend-4M and tend-6M (respectively 2, 4 and 6 months before tend) were analyzed to extract relevant variations among eleven perfusion biomarkers (B). These variations were assessed through R(B), as the absolute value of the ratio between ∆B from tend-4M to tend-2M and ∆B from tend-6M to tend-4M. The optimal cut-off for R(B) was determined using receiver-operating-characteristic curve analysis.Results: The fraction of hypoperfused tumor volume (F_hPg) was a relevant biomarker. A ratio R(F_hPg) ≥ 0.61 would have been able to anticipate relapse at the next follow-up with a sensitivity/specificity/accuracy of 92.3 %/63.6 %/79.2 %. High R(F_hPg) (≥0.61) was associated with more relapse at tend compared to low R(F_hPg) (75 % vs 12.5 %, p = 0.008).Conclusion: Iterative analysis of F_hPg from consecutive examinations could provide surrogate markers to predict progression at the next follow-up.Key Points: • Related rCBV biomarkers from DSC were assessed to anticipate GBM progression. • Biomarkers were assessed through their patterns of variation during the follow-up. • The fraction of hypoperfused tumour volume (F_hP g ) seemed to be a relevant biomarker. • An innovative ratio R(F_hP g ) could be an early surrogate marker of relapse. • A significant time gain could be achieved in the management of GBM patients.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        research
        tables/charts
        randomized controlled trial
        Journal Article
      ougenre: Article
    language: English
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