Histogram analysis of apparent diffusion coefficients after neoadjuvant chemotherapy in breast cancer.
Purpose: To evaluate the changes in the apparent diffusion coefficient (ADC) histogram during neoadjuvant chemotherapy (NAC) for breast cancer, and to compare the observed changes in pathologically verified responders and non-responders.Materials and Methods: Sixty-two patients received NAC followed...
| Publicado en: | Japanese Journal of Radiology Vol. 34; no. 10; pp. 657 - 667 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118561090&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118561090 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18671071 AUCM jtl: Japanese Journal of Radiology issn: 18671071 maglogo: N pubinfo: dt: Oct2016 vid: 34 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 118561090 118561090 143929564 NLM27517370 10.1007/s11604-016-0570-2 NLM27517370 118561090 ppf: 657 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Histogram analysis of apparent diffusion coefficients after neoadjuvant chemotherapy in breast cancer. aug: au: Kim, Yun Kim, Sung Lee, Ah Jin, Min-Sun Kang, Bong Song, Byung Kim, Yun Ju Kim, Sung Hun Lee, Ah Won Kang, Bong Joo Song, Byung Joo affil: Department of Radiology , National Cancer Center , Goyang Republic of Korea sug: subj: Breast Neoplasms Breast Neoplasms Drug Therapy Magnetic Resonance Imaging Methods Antineoplastic Agents Therapeutic Use Breast Neoplasms Surgery Middle Age Neoadjuvant Therapy Retrospective Design Treatment Outcomes Female Neoplasm Staging Adult Aged Scales Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Female ab: Purpose: To evaluate the changes in the apparent diffusion coefficient (ADC) histogram during neoadjuvant chemotherapy (NAC) for breast cancer, and to compare the observed changes in pathologically verified responders and non-responders.Materials and Methods: Sixty-two patients received NAC followed by surgery. Responders were defined by a tumor cell reduction of at least 30 % using the Miller-Payne grading system. All the patients underwent 3T magnetic resonance with diffusion-weighted imaging (b values of 0 and 750 s/mm2) before the NAC and after the completion of two cycles of NAC.Results: Mean, minimum, 10th, 25th, 50th, and 75th percentile of ADCs significantly increased after NAC and maximum ADC significantly decreased. Skewness became less positive and kurtosis decreased. A tendential, although not statistically significant, higher increase in mean, minimum, 10th, 25th, 50th, 75th, and 90th percentiles of ADCs was observed in responders in comparison with non-responders.Conclusion: ADC histogram analysis quantitatively demonstrates the alterations during the treatment course. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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