Effect of Xinjiang Uyghur Vernonia anthelmintica Willd Injection Treatment with Silicosis Fibrosis.
Objective. To observe the curative effect of VAWI on Xinjiang Uygur patients with silicosis fibrosis. Methods. After we diagnosed the 40 patients with the first phase of silicosis, we randomly divided them into two groups: the basic treatment group (group A, n=20) and the VAWI group (group B, n=20)....
| Publicado en: | BioMed Research International Vol. 2016; pp. 1 - 12 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | equations & formulas research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Wiley-Blackwell
10/10/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118707967&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118707967 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 10/10/2016 vid: 2016 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 118707967 118707967 118707967 10.1155/2016/5139651 118707967 ppf: 1 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Effect of Xinjiang Uyghur Vernonia anthelmintica Willd Injection Treatment with Silicosis Fibrosis. aug: au: Liu, Guitao Liu, Yingjia Jin, Lu Li, Cuidong Nie, Liping Wei, Yanhua Wang, Wenyu Xu, Yuhong Nusilaiti, Nuziguli Hua, Ping Li, Xiujuan Wang, Xiaohua Wei, Wenlong Wufuer, Hamulati affil: Department of Occupational Disease Prevention and Control, The Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, China sug: subj: Pneumoconiosis Drug Therapy Antibiotics Therapeutic Use Expectorants Therapeutic Use Drugs, Chinese Herbal Therapeutic Use Human Funding Source Randomized Controlled Trials Matched Case Control Protein Array Analysis Cluster Analysis Factor Analysis Mass Spectrometry Drug Therapy, Combination Pneumoconiosis Diagnosis Data Analysis Software T-Tests Chi Square Test Coefficient alpha Wilcoxon Rank Sum Test Discriminant Analysis Pneumoconiosis Pathology Decision Trees Sensitivity and Specificity Chinese Persons Proteins China ab: Objective. To observe the curative effect of VAWI on Xinjiang Uygur patients with silicosis fibrosis. Methods. After we diagnosed the 40 patients with the first phase of silicosis, we randomly divided them into two groups: the basic treatment group (group A, n=20) and the VAWI group (group B, n=20). At the same time, we selected the age-matched healthy patients (n=20). We applied the combined protein chip with SELDI-TOF-MS to carry out the serum analysis. The data were analyzed throughout data preprocessing, difference in PEAK screening, hierarchical cluster analysis, and Principal Component Analysis (PCA). We built decision tree model and predict the difference between the PEAK corresponding proteins. Results. The proteins peaks corresponding to name, predicted protein, and gene name were as follows: M2001_69, amyloid beta a4 protein, APP, and M2017_02, amyloid beta a4 protein, APP. The different expression of proteins in patients with silicosis was found before and after with VAWI treatment. The predicted proteins were as follows: M1982_50, amyloid beta a4 protein, APP; M3164_50, fibrinogen alpha chain frag, FGA; M3379_28, fibrinogen alpha chain frag, FGA; and so on. Conclusion. VAWI presented curative effect on patients with silicosis fibrosis via the alternation of proteins expression in serum. pubtype: Academic Journal doctype: equations & formulas research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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