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Objective Pupillary Correlates of Photosensitivity in the Normal and Mild Traumatic Brain Injury Populations.

Objective: No objective vision biomarker for photosensitivity currently exists. The present study sought to uncover potential biomarkers for photosensitivity within the pupillary light reflex.Methods: The pupillary light reflex was evaluated in those with mild traumatic brain injury (mTBI) and in no...

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Published in:Military Medicine Vol. 181; no. 10; pp. 1382 - 1391
Main Authors: Truong, James Q., Ciuffreda, Kenneth J.
Format: research tables/charts Journal Article
Published: Oxford University Press / USA Oct2016
Online Access:View this record in EBSCOhost
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      dt: Oct2016
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      pub: Oxford University Press / USA
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        atl: Objective Pupillary Correlates of Photosensitivity in the Normal and Mild Traumatic Brain Injury Populations.
      aug:
        au:
          Truong, James Q.
          Ciuffreda, Kenneth J.
        affil: Department of Biological and Vision Sciences, SUNY College of Optometry, 33 West 42nd Street, New York, NY, 10036.
      sug:
        subj:
          Reflex, Pupillary
          Physical Stimulation
          Pupil Physiology
          Adult
          Female
          Middle Age
          Male
          Human
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Female
          Male
      ab: Objective: No objective vision biomarker for photosensitivity currently exists. The present study sought to uncover potential biomarkers for photosensitivity within the pupillary light reflex.Methods: The pupillary light reflex was evaluated in those with mild traumatic brain injury (mTBI) and in normal individuals, with and without photosensitivity, under a range of test conditions. The Neuroptics DP-2000, infrared, binocular pupillometer was used for both binocular stimulation and recording. Twelve pupil parameters and 6 stimulus conditions were quantitatively assessed in 32 adults with mTBI and compared to 40 normal adult controls.Results: Normal subjects with photosensitivity exhibited four significant differences (p < 0.05) as compared with their nonphotosensitive cohort: larger constriction amplitude, faster average constriction velocity, faster peak constriction velocity, and slower recovery time. mTBI subjects with photosensitivity manifested six significant differences (p < 0.05) as compared with their nonphotosensitive cohort: larger baseline diameter, larger minimum diameter, faster peak dilation velocity, faster T50 and T75 recovery times, and a larger pupil diameter at 6 seconds poststimulus.Discussion: Several pupillometry parameters were significantly different in those with and without photosensitivity in both populations tested. These specific parameters could serve as potential, objectively based biomarkers for photosensitivity in these specific populations.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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