Translating nutritional immunology into drug development for inflammatory bowel disease.
Purpose Of Review: To highlight recent advances in the understanding of nutritional immunology and in the development of novel therapeutics for inflammatory bowel disease (IBD).Recent Findings: We highlight the variety of factors that contribute to the interaction of the immune system and nutrition...
| Publicado en: | Current Opinion in Gastroenterology Vol. 32; no. 6; pp. 443 - 450 |
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| Autores principales: | , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Nov2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118874406&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118874406 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02671379 IQT jtl: Current Opinion in Gastroenterology issn: 02671379 maglogo: N pubinfo: dt: Nov2016 vid: 32 iid: 6 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 118874406 118874406 NLM27673381 118874406 10.1097/MOG.0000000000000317 NLM27673381 118874406 ppf: 443 ppct: 7 formats: tig: atl: Translating nutritional immunology into drug development for inflammatory bowel disease. aug: au: Leber, Andrew Hontecillas, Raquel Tubau-Juni, Nuria Bassaganya-Riera, Josep affil: Nutritional Immunology and Molecular Medicine Laboratory, Biocomplexity Institute of Virginia Tech, Blacksburg, Virginia, USA. sug: subj: Drug Discovery Methods Nutritional Physiology Immunology Inflammatory Bowel Diseases Immunology Inflammatory Bowel Diseases Drug Therapy Research, Medical Methods Inflammatory Bowel Diseases Microbiology Drug Therapy Methods Gastrointestinal Agents Therapeutic Use ab: Purpose Of Review: To highlight recent advances in the understanding of nutritional immunology and in the development of novel therapeutics for inflammatory bowel disease (IBD).Recent Findings: We highlight the variety of factors that contribute to the interaction of the immune system and nutrition including the microbiome and the nervous system stimulation of the gut. We describe the potential for therapeutic development in IBD. Further, we review the cellular metabolic effects on immune activation and promising therapeutic targets. Finally, we show how the progression of understanding the role of lanthionine synthetase C-like 2 has encompassed both nutritional and therapeutic advances and led to the development of novel oral small molecule therapeutics for IBD.Summary: Nutritional immunology and drug development research centered around immunoregulatory pathways can provide safer and more effective drugs while accelerating the path to cures. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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