Tensor and non-tensor tractography for the assessment of the corticospinal tract of children with motor disorders: a comparative study.
Introduction: Non-invasive measures of corticospinal tract (CST) integrity may help to guide clinical interventions, particularly in children and young people (CAYP) with motor disorders. We compared diffusion tensor imaging (DTI) metrics extracted from the CST generated by tensor and non-tensor bas...
| Publicado en: | Neuroradiology Vol. 58; no. 10; pp. 1005 - 1017 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=118887601&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 118887601 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Oct2016 vid: 58 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 118887601 118887601 118887601 10.1007/s00234-016-1721-y 118887601 ppf: 1005 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Tensor and non-tensor tractography for the assessment of the corticospinal tract of children with motor disorders: a comparative study. aug: au: Stefanou, Maria-Ioanna Lumsden, Daniel Ashmore, Jonathan Ashkan, Keyoumars Lin, Jean-Pierre Charles-Edwards, Geoffrey affil: Complex Motor Disorder Service, Evelina London Children's Hospital , Guy's and St Thomas' NHS Foundation Trust , Westminister Bridge Road London SE1 7EH UK sug: subj: Pediatric Care Neural Pathways Analysis Imaging, Three-Dimensional Methods Movement Disorders Human Comparative Studies Child Adolescence Magnetic Resonance Imaging Algorithms Neurosurgery Child: 6-12 years Adolescent: 13-18 years ab: Introduction: Non-invasive measures of corticospinal tract (CST) integrity may help to guide clinical interventions, particularly in children and young people (CAYP) with motor disorders. We compared diffusion tensor imaging (DTI) metrics extracted from the CST generated by tensor and non-tensor based tractography algorithms. Methods: For a group of 25 CAYP undergoing clinical evaluation, the CST was reconstructed using (1) deterministic tensor-based tractography algorithm, (2) probabilistic tensor-based, and (3) constrained spherical deconvolution (CSD)-derived tractography algorithms. Results: Choice of tractography algorithm significantly altered the results of tracking. Larger tracts were consistently defined with CSD, with differences in FA but not MD values for tracts to the pre- or post-central gyrus. Differences between deterministic and probabilistic tensor-based algorithms were minimal. Non-tensor reconstructed tracts appeared to be more anatomically representative. Examining metrics along the tract, difference in FA values appeared to be greatest in voxels with predominantly single-fibre orientations. Less pronounced differences were seen outwith of these regions. Conclusion: With an increasing interest in the applications of tractography analysis at all stages of movement disorder surgery, it is important that clinicians remain alert to the consequences of choice of tractography algorithm on subsequently generated tracts, including differences in volumes, anatomical reconstruction, and DTI metrics, the latter of which will have global as well as more regional effects. Tract-wide analysis of DTI based metrics is of limited utility, and a more segmental approach to analysis may be appropriate, particularly if disruption to a focal region of a white matter pathway is anticipated. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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