Origins of Selectivity and General Model for Chiral Phosphoric Acid-Catalyzed Oxetane Desymmetrizations.

The origins of the high enantioselectivity of chiral phosphoric acid-catalyzed oxetane desymmetrizations were investigated by density functional theory (DFT) calculations. Distortion of the catalyst structure, caused by steric crowding in the catalyst pocket of one enantiomeric transition state, is...

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Publicado en:	Journal of the American Chemical Society Vol. 138; no. 38; pp. 12356 - 12360
Autores principales:	Champagne, Pier Alexandre, Houk, K. N.
Formato:	Artículo
Publicado:	American Chemical Society 9/28/2016
Materias:	Phosphoric acid Catalyst synthesis Stereochemistry Proton transfer reactions Asymmetric synthesis Density functional theory
Acceso en línea:	Ver este registro en EBSCOhost