A computational framework for converting textual clinical diagnostic criteria into the quality data model.

Background: Constructing standard and computable clinical diagnostic criteria is an important but challenging research field in the clinical informatics community. The Quality Data Model (QDM) is emerging as a promising information model for standardizing clinical diagnostic criteria.Objective: To d...

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Published in:Journal of Biomedical Informatics Vol. 63; pp. 11 - 22
Main Authors: Hong, Na, Li, Dingcheng, Yu, Yue, Xiu, Qiongying, Liu, Hongfang, Jiang, Guoqian
Format: research Journal Article
Published: Academic Press Inc. Oct2016
Online Access:View this record in EBSCOhost
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      dt: Oct2016
      vid: 63
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      pub: Academic Press Inc.
      place: Burlington, Massachusetts
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        10.1016/j.jbi.2016.07.016
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        118967219
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        atl: A computational framework for converting textual clinical diagnostic criteria into the quality data model.
      aug:
        au:
          Hong, Na
          Li, Dingcheng
          Yu, Yue
          Xiu, Qiongying
          Liu, Hongfang
          Jiang, Guoqian
        affil: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
      sug:
        subj:
          Diagnosis, Computer Assisted
          Natural Language Processing
          Algorithms
          Human
      ab: Background: Constructing standard and computable clinical diagnostic criteria is an important but challenging research field in the clinical informatics community. The Quality Data Model (QDM) is emerging as a promising information model for standardizing clinical diagnostic criteria.Objective: To develop and evaluate automated methods for converting textual clinical diagnostic criteria in a structured format using QDM.Methods: We used a clinical Natural Language Processing (NLP) tool known as cTAKES to detect sentences and annotate events in diagnostic criteria. We developed a rule-based approach for assigning the QDM datatype(s) to an individual criterion, whereas we invoked a machine learning algorithm based on the Conditional Random Fields (CRFs) for annotating attributes belonging to each particular QDM datatype. We manually developed an annotated corpus as the gold standard and used standard measures (precision, recall and f-measure) for the performance evaluation.Results: We harvested 267 individual criteria with the datatypes of Symptom and Laboratory Test from 63 textual diagnostic criteria. We manually annotated attributes and values in 142 individual Laboratory Test criteria. The average performance of our rule-based approach was 0.84 of precision, 0.86 of recall, and 0.85 of f-measure; the performance of CRFs-based classification was 0.95 of precision, 0.88 of recall and 0.91 of f-measure. We also implemented a web-based tool that automatically translates textual Laboratory Test criteria into the QDM XML template format. The results indicated that our approaches leveraging cTAKES and CRFs are effective in facilitating diagnostic criteria annotation and classification.Conclusion: Our NLP-based computational framework is a feasible and useful solution in developing diagnostic criteria representation and computerization.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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