Chronotherapy: Intuitive, Sound, Founded...But Not Broadly Applied.
Circadian rhythms are a collection of endogenously driven biochemical, physiological, and behavioral processes that oscillate in a 24-h cycle and can be entrained by external cues. Circadian clock molecules are responsible for the expression of regulatory components that modulate, among others, the...
| Publicado en: | Drugs Vol. 76; no. 16; pp. 1507 - 1522 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119091090&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119091090 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00126667 C5A jtl: Drugs issn: 00126667 maglogo: N pubinfo: dt: Oct2016 vid: 76 iid: 16 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 119091090 119091090 143926008 119091090 10.1007/s40265-016-0646-4 119091090 ppf: 1507 ppct: 15 formats: tig: atl: Chronotherapy: Intuitive, Sound, Founded...But Not Broadly Applied. aug: au: Selfridge, Julia Gotoh, Tetsuya Schiffhauer, Samuel Liu, JingJing Stauffer, Philip Li, Andrew Capelluto, Daniel Finkielstein, Carla affil: Integrated Cellular Responses Laboratory, Department of Biological Sciences , Biocomplexity Institute , 1015 Life Science Circle, Virginia Tech Blacksburg 24061 USA sug: subj: Chronotherapy Circadian Rhythm Chronobiology Disorders Genes Gene Expression Genomics Drugs Pharmacodynamics Drug Administration Schedule Pharmacokinetics ab: Circadian rhythms are a collection of endogenously driven biochemical, physiological, and behavioral processes that oscillate in a 24-h cycle and can be entrained by external cues. Circadian clock molecules are responsible for the expression of regulatory components that modulate, among others, the cell's metabolism and energy consumption. In clinical practice, the regulation of clock mechanisms is relevant to biotransformation of therapeutics. Accordingly, xenobiotic metabolism and detoxification, the two processes that directly influence drug effectiveness and toxicity, are direct manifestations of the daily oscillations of the cellular and biochemical processes taking place within the gastrointestinal, hepatic/biliary, and renal/urologic systems. Consequently, the impact of circadian timing should be factored in when developing therapeutic regimens aimed at achieving maximum efficacy, minimum toxicity, and decreased adverse effects in a patient. However, and despite a strong mechanistic foundation, only 0.16 % of ongoing clinical trials worldwide exploit the concept of 'time-of-day' administration to develop safer and more effective therapies. In this article, we (1) emphasize points of control at which circadian biology intersects critical processes governing treatment interventions; (2) explore the extent to which chronotherapeutics are incorporated into clinical trials; (3) recognize roadblocks; and (4) recommend approaches to precipitate the integration of chronobiological concepts into clinical practice. pubtype: Academic Journal doctype: pictorial tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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