Effects of ω -3 Fatty Acids and Catechins on Fatty Acid Synthase in the Prostate: A Randomized Controlled Trial.
Animal and human studies suggest fish oil and green tea may have protective effect on prostate cancer. Fatty acid synthase (FAS) has been hypothesized to be linked to chemoprotective effects of both compounds. This study evaluated the independent and joint effects of fish oil (FO) and green tea supp...
| Published in: | Nutrition & Cancer Vol. 68; no. 8; pp. 1309 - 1320 |
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| Main Authors: | , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Taylor & Francis Ltd
Nov/Dec2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119148501&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119148501 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: Nov/Dec2016 vid: 68 iid: 8 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 119148501 119148501 119148501 10.1080/01635581.2016.1224365 119148501 ppf: 1309 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effects of ω -3 Fatty Acids and Catechins on Fatty Acid Synthase in the Prostate: A Randomized Controlled Trial. aug: au: Zhang, Zhenzhen Garzotto, Mark Beer, Tomasz M. Thuillier, Philippe Lieberman, Stephen Mori, Motomi Stoller, Wesley A. Farris, Paige E. Shannon, Jackilen affil: OHSU-PSU School of Public Health, Oregon Health and Science University, Portland, Oregon, USA sug: subj: Fatty Acids, omega-3 Tannins Therapeutic Use Prostate Physiology Nutrition Human Randomized Controlled Trials Enzymes Male Prostatic Neoplasms Prevention and Control Prostatic Neoplasms Physiopathology Chemoprevention Fish Oils Therapeutic Use Green Tea Therapeutic Use Prostate Anatomy and Histology Immunohistochemistry Placebos Urology Research Subject Recruitment Prostate-Specific Antigen Analysis Prostate-Specific Antigen Blood Biopsy Tissue and Organ Harvesting Chromatography Data Analysis Analysis of Variance Data Analysis Software Chi Square Test Confidence Intervals Patient Assessment Middle Age Kruskal-Wallis Test Middle Aged: 45-64 years Male ab: Animal and human studies suggest fish oil and green tea may have protective effect on prostate cancer. Fatty acid synthase (FAS) has been hypothesized to be linked to chemoprotective effects of both compounds. This study evaluated the independent and joint effects of fish oil (FO) and green tea supplement (epigallocatechin-3-gallate, EGCG) on FAS and Ki-67 levels in prostate tissue. Through a double-blinded, randomized controlled trial with 2 × 2 factorial design, 89 men scheduled for repeat prostate biopsy following an initial negative prostate biopsy were randomized into either FO alone (1.9 g DHA + EPA/day), EGCG alone (600 mg/day), a combination of FO and EGCG, or placebo. We used linear mixed-effects models to test the differences of prostate tissue FAS and Ki-67 by immunohistochemistry between pre- and post-intervention within each group, as well as between treatment groups. Results did not show significant difference among treatment groups in pre-to-post-intervention changes of FAS (P= 0.69) or Ki-67 (P= 0.26). Comparing placebo group with any of the treatment groups, we did not find significant difference in FAS or Ki-67 changes (allP> 0.05). Results indicate FO or EGCG supplementation for a short duration may not be sufficient to produce biologically meaningful changes in FAS or Ki-67 levels in prostate tissue. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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