Inhibitory Kinetics and Mechanism of Flavonoids Extracted from Cotinus coggygria Scop. Against Glioblastoma Cancer.
This proposal seeks to study the potential therapeutic modality of chemoprevention and anticancer effects and mechanisms of the flavonoids fromCotinus coggygriaScop. on glioblastoma cancer. In the current study, the total flavonoids (TFs) isolated fromCotinus coggygriaScop. var. cinerea Engl. (Cotin...
| Publicado en: | Nutrition & Cancer Vol. 68; no. 8; pp. 1357 - 1369 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Nov/Dec2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119148511&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119148511 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: Nov/Dec2016 vid: 68 iid: 8 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 119148511 119148511 119148511 10.1080/01635581.2016.1225105 119148511 ppf: 1357 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Inhibitory Kinetics and Mechanism of Flavonoids Extracted from Cotinus coggygria Scop. Against Glioblastoma Cancer. aug: au: Wang, Gang Wang, Jun-Jie Du, Li Fei, Li To, Shing-shun Tony affil: Department of Pharmaceutics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai, China sug: subj: Plants, Medicinal Therapeutic Use Flavonoids Therapeutic Use Kinetics Glioma Prevention and Control Nutrition Animal Studies Chemoprevention Cell Physiology Medicine, Herbal Mice Mass Spectrometry Flow Cytometry Biological Assay Blotting, Western Methods Flavonoids Classification Apoptosis Antineoplastic Agents ab: This proposal seeks to study the potential therapeutic modality of chemoprevention and anticancer effects and mechanisms of the flavonoids fromCotinus coggygriaScop. on glioblastoma cancer. In the current study, the total flavonoids (TFs) isolated fromCotinus coggygriaScop. var. cinerea Engl. (Cotinus coggygriaScop.) and the major flavonoids ofCotinus coggygriaScop. (CCFs) were identified, and the inhibitory kinetics of TF and CCF on glioblastoma cell lines were calculated. We also investigated whether TF or CCF regulated the apoptotic mechanism in cellular models of glio-blastoma cells. Finally, we evaluated whether treatment with TF or CCF suppressed tumor growth and inhibited migration in orthotopic mouse models of glioblastoma in vivo. In this study, the CCFs were identified as rutin, myricetin, and fisetin. TF and CCF remarkably inhibited cell proliferation and downregulated the PI3K/Akt and ERK signaling pathway in glioblastoma cell lines. Furthermore, the mitochondrial caspase-dependent cascade was regulated by TF and myricetin. In addition, TF and myricetin exhibited significant antitumor effects on glioblastoma in vivo. Taken together, these results suggest that phytochemical and biological data provide evidence for the active components inCotinus coggygria, and that the TFs are responsible for the anticancer effects on glioblastoma cell growth via induction of apoptosis. In addition, the representative compound myricetin could provide a clinically relevant therapeutic opportunity. Therefore, our data strongly suggest that myricetin-deprived CCF can serve as a potent chemopreventive herbal medicine. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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