Do More With Less.
* Context.--In an era in which testing of patient tumor material for molecular and other ancillary studies is of increasing clinical importance for selection of therapy, the ability to test on small samplings becomes critical. Often, small samplings are rapidly depleted in the diagnostic workup or a...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 140; no. 11; pp. 1206 - 1221 |
|---|---|
| Autores principales: | , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
College of American Pathologists
Nov2016
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119227548&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119227548 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Nov2016 vid: 140 iid: 11 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 119227548 119227548 119227548 10.5858/arpa.2016-0156-RA 119227548 ppf: 1206 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Do More With Less. aug: au: Aisner, Dara L. Rumery, Mathew D. Merrick, Daniel T. Kondo, Kimi L. Nijmeh, Hala Linderman, Derek J. Doebele, Robert C. Thomas, Natalie Chesnut, Patrick C. Varella-Garcia, Marileila Franklin, Wilbur A. Camidge, D. Ross affil: Department of Pathology, University of Colorado, Aurora sug: subj: Specimen Handling Methods Histocytological Preparation Techniques Molecular Diagnostic Techniques Biological Markers Analysis Academic Medical Centers Colorado Colorado Biopsy Workload Pathology, Molecular Retrospective Design Evaluation Research Female Male Human Funding Source Female Male ab: * Context.--In an era in which testing of patient tumor material for molecular and other ancillary studies is of increasing clinical importance for selection of therapy, the ability to test on small samplings becomes critical. Often, small samplings are rapidly depleted in the diagnostic workup or are insufficient for multiple ancillary testing approaches. Objective.--To describe technical methodologies that can be implemented to preserve and maximize tissue for molecular and other ancillary testing. Data Sources.--Retrospective analysis of a case cohort from the University of Colorado, description of techniques used at the University of Colorado, and published literature. Conclusions.--Numerous techniques can be deployed to maximize molecular and other ancillary testing, even when specimens are from small samplings. A dedicated process for molecular prioritization has a high success rate, but also increases workload, which must be factored into establishing such a process. Additionally, establishing high- fidelity communication strings is critical for success of dedicated molecular prioritization of samples. Numerous approaches can be deployed for alternative specimen types, and several technical approaches can also aid in maximizing small specimens. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|