Automatic Oxygen Titration During Walking in Subjects With COPD: A Randomized Crossover Controlled Study.
BACKGROUND: Arterial oxygen desaturation frequently occurs in patients with COPD during daily activities at home. Oxygen flow is usually set at fixed and low rates for ambulatory patients. We evaluated an innovative closed-loop system (FreeO2) that automatically adjusts the oxygen flow to the patien...
| Publicado en: | Respiratory Care Vol. 61; no. 11; pp. 1456 - 1465 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Nov2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119227665&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119227665 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Nov2016 vid: 61 iid: 11 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 119227665 119227665 119227665 10.4187/respcare.04406 119227665 ppf: 1456 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Automatic Oxygen Titration During Walking in Subjects With COPD: A Randomized Crossover Controlled Study. aug: au: Lellouche, François L'Her, Erwan Bouchard, Pierre-Alexandre Brouillard, Cynthia Maltais, François affil: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Quebec, Canada sug: subj: Oxygen Therapy Pulmonary Disease, Chronic Obstructive Walking Anoxia Hyperoxia Human Randomized Controlled Trials Quebec Scales T-Tests Cox Proportional Hazards Model Oxygenation Evaluation Respiratory Function Tests Body Mass Index Physical Endurance Evaluation Dyspnea Exercise Tolerance Evaluation Funding Source ab: BACKGROUND: Arterial oxygen desaturation frequently occurs in patients with COPD during daily activities at home. Oxygen flow is usually set at fixed and low rates for ambulatory patients. We evaluated an innovative closed-loop system (FreeO2) that automatically adjusts the oxygen flow to the patient's needs in subjects with COPD during walking followed by recovery time, such as during ambulatory conditions. METHODS: Patients with COPD who exhibited oxygen desaturation on exertion were included in the study. Subjects performed endurance shuttle walk tests followed by 10 min of recovery. The tests were conducted in a random order and in crossover with the 3 following conditions: subjects breathing (1) air at 2 L/min, (2) oxygen at 2 L/min, or (3) FreeO2 (variable oxygen flow). ..., pulse rate, ... breathing frequency, and oxygen flow were continuously recorded during the 3 conditions. The primary outcome was the percentage of time within the ... target of 92-96%. Secondary outcomes included the endurance shuttle walk test time and distance. RESULTS: Sixteen subjects with COPD were recruited. The percentage of time with ... in the target range (92-96%) was higher while using the FreeO2. and time with severe oxygen desaturation ... <88%) was lower with Free02 in comparison with constant-flow oxygen and air testing conditions (0.6% vs 23.9% vs 52.2%, P < .001). In comparison with air, walking distance was increased by 35% with oxygen (P - .045) and by 63% with FreeO2 (P < .001). The walking distance was increased by 17% with FreeO2 in comparison with constant oxygen, but the difference was not statistically significant (P = .22). CONCLUSIONS: Automatic titration of oxygen flow during walking to maintain oxygen saturation in a specified range improves oxygenation and may improve exercise tolerance during daily activity, such as walking, in patients with COPD in comparison with room air and fixed oxygen administration. (ClinicalTrials.gov registration: NCT02150434.) pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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