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New Predictor of Atherosclerosis in Subjects With COPD: Atherogenic Indices.

BACKGROUND: We aimed to investigate the predictor role of the plasma levels of lipid parameters and atherogenic indices on development of atherosclerosis in subjects with COPD. METHODS: We retrospectively analyzed 104 male subjects diagnosed with stable COPD in hospital records. We excluded subjects...

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Published in:Respiratory Care Vol. 61; no. 11; pp. 1481 - 1488
Main Authors: Gunay, Sibel, Sariaydin, Muzaffer, Acay, Akif
Format: research tables/charts Journal Article
Published: Mary Ann Liebert, Inc. Nov2016
Online Access:View this record in EBSCOhost
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      dt: Nov2016
      vid: 61
      iid: 11
      pid: 1365
      pub: Mary Ann Liebert, Inc.
      place: New Rochelle, New York
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        10.4187/respcare.04796
        119227668
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        atl: New Predictor of Atherosclerosis in Subjects With COPD: Atherogenic Indices.
      aug:
        au:
          Gunay, Sibel
          Sariaydin, Muzaffer
          Acay, Akif
        affil: Chest Disease Clinic, Afyon State Hospital, Afyonkarahisar, Turkey
      sug:
        subj:
          Pulmonary Disease, Chronic Obstructive
          Comorbidity
          Atherosclerosis Risk Factors
          Human
          Descriptive Research
          Descriptive Statistics
          Predictive Research
          Retrospective Design
          Control Group
          Record Review
          Medical Records
          C-Reactive Protein
          Lipoproteins Analysis
          Turkiye
          Convenience Sample
          International Classification of Diseases
          Body Mass Index
          Respiratory Function Tests
          Adult
          Middle Age
          Aged
          Male
          Pilot Studies
          T-Tests
          Chi Square Test
          Hematologic Tests
          Spearman's Rank Correlation Coefficient
          Multiple Linear Regression
          Cross Sectional Studies
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Aged: 65+ years
          Male
      ab: BACKGROUND: We aimed to investigate the predictor role of the plasma levels of lipid parameters and atherogenic indices on development of atherosclerosis in subjects with COPD. METHODS: We retrospectively analyzed 104 male subjects diagnosed with stable COPD in hospital records. We excluded subjects with exacerbation, with known cardiovascular diseases and other chronic diseases, receiving anti-hyperlipidemic treatment, without sufficient past medical history, and lacking needed laboratory data. Additionally, 40 age-matched male healthy controls were also enrolled. C-reactive protein, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high- density lipoprotein cholesterol levels of COPD and the control group were analyzed. Atherogenic indices (atherogenic index of plasma, cardiogenic risk ratio, and atherogenic coefficient) were calculated. RESULTS: C-reactive protein, triglyceride, atherogenic index of plasma, cardiogenic risk ratio, and atherogenic coefficient values were significantly higher in subjects with stable COPD than in control subjects (P < .05 for all). High-density lipoprotein cholesterol level was significantly lower in subjects with COPD than in the control group (P < .001). C-reactive protein, lipid profiles, and atherogenic indices were similar in lower-risk (stage A and B) and higher-risk (stage C and D) subjects with COPD. Cardiogenic risk ratio and atherogenic coefficient were negatively correlated with FEV, in all stable subjects with COPD and in higher-risk subjects with COPD (r = -0.27, P = .01 and r = -0.35, P = .01, respectively). CONCLUSIONS: We concluded that atherogenic indices (atherogenic index of plasma, cardiogenic risk ratio, atherogenic coefficient) could be considered as a useful predictor for atherosclerosis and cardiovascular diseases in stable COPD patients. Nevertheless, further prospective investigations on this issue are warranted.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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