Does size reliably predict malignancy in soft tissue tumours?
Purpose: In this retrospective study we examined whether size is a viable marker of tumour malignancy in soft tissue masses (STM) and if the ratio of width and length (RALD) of an STM reflects tumour biology more accurately.Methods: Measurements of maximal lesion size and perpendicular diameter were...
| Publicado en: | European Radiology Vol. 26; no. 12; pp. 4640 - 4649 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119335390&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119335390 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Dec2016 vid: 26 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 119335390 119335390 NLM26960540 119335390 10.1007/s00330-016-4300-z NLM26960540 119335390 ppf: 4640 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Does size reliably predict malignancy in soft tissue tumours? aug: au: Gruber, Leonhard Loizides, Alexander Glodny, Bernhard Plaikner, Michaela Gruber, Hannes Ostermann, Laurin affil: Department of Radiology , Medical University Innsbruck , Anichstraße 35 6020 Innsbruck Austria sug: subj: Soft Tissue Neoplasms Pathology Ultrasonography Methods Magnetic Resonance Imaging Methods Soft Tissue Neoplasms Middle Age Predictive Value of Tests Reproducibility of Results Female Male Severity of Illness Indices Retrospective Design Sensitivity and Specificity Human Middle Aged: 45-64 years Female Male ab: Purpose: In this retrospective study we examined whether size is a viable marker of tumour malignancy in soft tissue masses (STM) and if the ratio of width and length (RALD) of an STM reflects tumour biology more accurately.Methods: Measurements of maximal lesion size and perpendicular diameter were performed in available MRI and ultrasonography studies of 212 patients (mean age 54.4 ± 17.2 years, male:female 1:1.12) with a histologically verified diagnosis.Results: Overall, 28.2 % of lesions were malignant, 11.1 % intermediate, and 58.8 % benign. Size alone was a weak predictor of malignancy in STMs (sensitivity 68.8 %, specificity 50.3 %, positive predictive value [PPV] 44.0 %, negative predictive value [NPV] 80.4 %). RALD showed better discriminatory power with greater separation between benign and malignant entities and higher values for sensitivity (83.6 %), specificity (53.6 %), and NPV (89.0 %). A weighted combination of size, age and RALD improved diagnostic power, demonstrating higher values for sensitivity (77.0 %), specificity (80.1 %), PPV (61.0 %), and NPV (89.6 %).Conclusions: Size should not be used alone to estimate an STM's malignancy. RALD better reflects a lesion's growth pattern and a combination of age, size, and RALD helps to discriminate more accurately between benign, intermediate, and malignant entities. These findings should help to estimate easily whether a newly found STM is benign or malignant prior to further workup.Key Points: •Size does not reliably differentiate between benign, intermediate, and malignant tumours •The R ALD (ratio of lateral to axial diameter) improves diagnostic confidence •When combined with age and size, STM differentiation was further enhanced •These measurements can aid in earlier detection of sarcomas. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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