Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum?
Background: Pyoderma gangrenosum is a rare inflammatory skin condition. Two prospective studies have evaluated treatments for pyoderma gangrenosum using a primary outcome of healing speed at 6 weeks.Objective: Using data from both studies we assessed the predictive value of 3 early predictors for he...
| Publicado en: | Journal of the American Academy of Dermatology Vol. 75; no. 6; pp. 1216 - 1217 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Elsevier B.V.
Dec2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119440423&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119440423 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01909622 1ZF jtl: Journal of the American Academy of Dermatology issn: 01909622 maglogo: N pubinfo: dt: Dec2016 vid: 75 iid: 6 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 119440423 119440423 NLM27742168 10.1016/j.jaad.2016.07.049 NLM27742168 119440423 ppf: 1216 ppct: 1 formats: tig: atl: Is speed of healing a good predictor of eventual healing of pyoderma gangrenosum? aug: au: Wilkes, Sally R. Williams, Hywel C. Ormerod, Anthony D. Craig, Fiona E. Greenlaw, Nicola Norrie, John Mitchell, Eleanor J. Mason, James M. Thomas, Kim S. affil: Center of Evidence-Based Dermatology, University of Nottingham, Nottingham, United Kingdom sug: subj: Severity of Illness Indices Pyoderma Gangrenosum Drug Therapy Wound Healing Middle Age Pyoderma Gangrenosum Complications Biological Assay Adult Pharmacokinetics Time Factors Aged Clinical Trials ROC Curve Female Inflammation Etiology Treatment Outcomes Male Inflammation Drug Therapy Predictive Value of Tests Scales Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Female Male ab: Background: Pyoderma gangrenosum is a rare inflammatory skin condition. Two prospective studies have evaluated treatments for pyoderma gangrenosum using a primary outcome of healing speed at 6 weeks.Objective: Using data from both studies we assessed the predictive value of 3 early predictors for healing at 6 months: speed of healing, Investigator Global Assessment (IGA), and resolution of inflammation, recorded at 2 and 6 weeks.Methods: Logistic regression models were applied and the effectiveness of the 3 measures was assessed through estimating the positive and negative predictive values and the area under the receiver operating characteristic curve.Results: The positive and negative predictive value at 6 weeks were, respectively, 63.5% (95% confidence interval [CI] 52.4%-73.7%) and 74.6% (95% CI 62.5%-84.5%) for speed of healing; 80% (95% CI 68.7%-88.6%) and 74.2% (95% CI 64.1%-82.7%) for IGA; and 72.1% (95% CI 59.9%-82.3%) and 68.1% (95% CI 57.7%-77.3%) for resolution of inflammation. IGA had the best combined positive predictive value, negative predictive value, and area under the receiver operating characteristic curve at 2 and 6 weeks.Limitations: We were limited by data available from existing datasets.Conclusion: Speed of healing, IGA, and resolution of inflammation were all shown to be good predictors of eventual healing of pyoderma gangrenosum. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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