Yeast β–Glucan Modulates Inflammation and Waist Circumference in Overweight and Obese Subjects.
Increased inflammation occurs with excessive adiposity and yeast β-glucan modulates immune responses. This study investigated the potential effect of yeast β-glucan on inflammatory cytokines in overweight/obese people. A randomized, double blinded, placebo-controlled, clinical trial design enrolled...
| Publicado en: | Journal of Dietary Supplements Vol. 14; no. 2; pp. 173 - 186 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Taylor & Francis Ltd
2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119451472&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119451472 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19390211 2Y62 jtl: Journal of Dietary Supplements issn: 19390211 maglogo: N pubinfo: dt: 2017 vid: 14 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 119451472 119451472 119451472 10.1080/19390211.2016.1207005 119451472 ppf: 173 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Yeast β–Glucan Modulates Inflammation and Waist Circumference in Overweight and Obese Subjects. aug: au: Mosikanon, Krittiya Arthan, Dumrongkiet Kettawan, Aikkarach Tungtrongchitr, Rungsunn Prangthip, Pattaneeya affil: Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand sug: subj: Obesity Physiopathology beta-Glucans Therapeutic Use Yeasts Inflammation Immunology Waist Circumference Human Immune System Drug Effects beta-Glucans Immunology Adipose Tissue Physiopathology Cytokines Drug Effects Randomized Controlled Trials Double-Blind Studies Body Mass Index Random Assignment beta-Glucans Pharmacodynamics Interleukins Drug Effects P-Value Descriptive Statistics Tumor Necrosis Factor Drug Effects Blood Pressure Drug Effects ab: Increased inflammation occurs with excessive adiposity and yeast β-glucan modulates immune responses. This study investigated the potential effect of yeast β-glucan on inflammatory cytokines in overweight/obese people. A randomized, double blinded, placebo-controlled, clinical trial design enrolled 44 overweight/obese participants with body mass index ≥23 kg/m2, randomized to two groups receiving β–glucan 477 mg/capsule (n = 22) or placebo (n = 22) orally for six weeks. At weeks one to two, participants received 1 β–glucan or placebo capsule/day and at four weeks two tablets/day. Anthropometric changes, lipid profiles, liver and renal functions, and inflammatory cytokines were measured. β-glucan reduced waist circumference (p = 0.037) and blood pressure (p = 0.006) compared with controls after six weeks of intervention. No statistical significance between groups was observed for triglyceride, cholesterol, lipid profile, liver and renal function, or energy and nutrient intake compared with controls at week six. β-glucan increased interlukin-10 (IL-10), an anti-inflammatory cytokine, by 23.97% from baseline at week two (p < 0.001) and 31.12% at week six (p < 0.001) and was significantly increased compared with controls at week two (p < 0.001) until week six (p < 0.001). β-glucan reduced pro-inflammatory cytokines IL-6 at week six (p = 0.005) and tumor necrosis factor-α at week two (p = 0.037) compared with controls. Supplementation of yeast β-glucan for six weeks modulated pro-cytokines that accelerate overweight/obese comorbidities and reduced blood pressure as well as waist circumference, the strong risk factors for cardiovascular disease, in overweight/obese subjects. Thus, β-glucan might have the potential to decrease comorbid conditions associated with overweight/ obesity. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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