Investigating the prostate specific antigen, body mass index and age relationship: is an age-BMI-adjusted PSA model clinically useful?
Purpose: Previous studies indicate a possible inverse relationship between prostate-specific antigen (PSA) and body mass index (BMI), and a positive relationship between PSA and age. We investigated the associations between age, BMI, PSA, and screen-detected prostate cancer to determine whether an a...
| Publicado en: | Cancer Causes & Control Vol. 27; no. 12; pp. 1465 - 1475 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119456338&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119456338 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09575243 ODX jtl: Cancer Causes & Control issn: 09575243 maglogo: N pubinfo: dt: Dec2016 vid: 27 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 119456338 119456338 144112169 NLM27830401 119456338 10.1007/s10552-016-0827-1 NLM27830401 119456338 ppf: 1465 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Investigating the prostate specific antigen, body mass index and age relationship: is an age-BMI-adjusted PSA model clinically useful? aug: au: Harrison, Sean Tilling, Kate Turner, Emma Lane, J. Simpkin, Andrew Davis, Michael Donovan, Jenny Hamdy, Freddie Neal, David Martin, Richard Turner, Emma L Lane, J Athene Hamdy, Freddie C Neal, David E Martin, Richard M affil: School of Social and Community Medicine , University of Bristol , Canynge Hall, 39 Whatley Road Bristol BS8 2PS UK sug: subj: Prostatic Neoplasms Epidemiology Prostate-Specific Antigen Analysis Blood Coagulation Factors Analysis Obesity Epidemiology Male Aged Age Factors Case Control Studies Clinical Trials Cross Sectional Studies Early Detection of Cancer Prostatic Neoplasms Diagnosis Middle Age Body Mass Index Human Aged: 65+ years Middle Aged: 45-64 years Male ab: Purpose: Previous studies indicate a possible inverse relationship between prostate-specific antigen (PSA) and body mass index (BMI), and a positive relationship between PSA and age. We investigated the associations between age, BMI, PSA, and screen-detected prostate cancer to determine whether an age-BMI-adjusted PSA model would be clinically useful for detecting prostate cancer.Methods: Cross-sectional analysis nested within the UK ProtecT trial of treatments for localized cancer. Of 18,238 men aged 50-69 years, 9,457 men without screen-detected prostate cancer (controls) and 1,836 men with prostate cancer (cases) met inclusion criteria: no history of prostate cancer or diabetes; PSA < 10 ng/ml; BMI between 15 and 50 kg/m2. Multivariable linear regression models were used to investigate the relationship between log-PSA, age, and BMI in all men, controlling for prostate cancer status.Results: In the 11,293 included men, the median PSA was 1.2 ng/ml (IQR: 0.7-2.6); mean age 61.7 years (SD 4.9); and mean BMI 26.8 kg/m2 (SD 3.7). There were a 5.1% decrease in PSA per 5 kg/m2 increase in BMI (95% CI 3.4-6.8) and a 13.6% increase in PSA per 5-year increase in age (95% CI 12.0-15.1). Interaction tests showed no evidence for different associations between age, BMI, and PSA in men above and below 3.0 ng/ml (all p for interaction >0.2). The age-BMI-adjusted PSA model performed as well as an age-adjusted model based on National Institute for Health and Care Excellence (NICE) guidelines at detecting prostate cancer.Conclusions: Age and BMI were associated with small changes in PSA. An age-BMI-adjusted PSA model is no more clinically useful for detecting prostate cancer than current NICE guidelines. Future studies looking at the effect of different variables on PSA, independent of their effect on prostate cancer, may improve the discrimination of PSA for prostate cancer. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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