Influence of the analysis technique on estimating hepatic iron content using MRI.
Purpose: To investigate the effect of the analysis technique on estimating hepatic iron content using MRI.Materials and Methods: We evaluated the influences of single-exponential (EXP), bi-exponential (BEXP), and exponential-plus-constant (CEXP) models; and pixel-wise (MAP), average (AVG), and media...
| Publicado en: | Journal of Magnetic Resonance Imaging Vol. 44; no. 6; pp. 1448 - 1456 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Dec2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119459069&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119459069 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10531807 O63 jtl: Journal of Magnetic Resonance Imaging issn: 10531807 maglogo: Y pubinfo: dt: Dec2016 vid: 44 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 119459069 119459069 NLM27240936 119459069 10.1002/jmri.25317 NLM27240936 119459069 ppf: 1448 ppct: 8 formats: tig: atl: Influence of the analysis technique on estimating hepatic iron content using MRI. aug: au: Ibrahim, El‐Sayed H. Khalifa, Ayman M. Eldaly, Ahmed K. Ibrahim, El-Sayed H affil: Department of Radiology, University of Michigan, Ann Arbor Michigan, USA sug: subj: Magnetic Resonance Imaging Methods Liver Image Interpretation, Computer Assisted Methods Anemia, Sickle Cell Metabolism Liver Metabolism Anemia, Sickle Cell Iron Metabolism Algorithms Adult Molecular Imaging Methods Reproducibility of Results Male Sensitivity and Specificity Female Human Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adult: 19-44 years Male Female ab: Purpose: To investigate the effect of the analysis technique on estimating hepatic iron content using MRI.Materials and Methods: We evaluated the influences of single-exponential (EXP), bi-exponential (BEXP), and exponential-plus-constant (CEXP) models; and pixel-wise (MAP), average (AVG), and median (MED) signal calculation methods on T2* measurement using numerical simulations, calibrated phantoms, and nine patients scanned on 3 Tesla MRI, based on regression, correlation, and t-test statistical analysis.Results: The T2* measurement error varied from 9 to 51% in the numerical simulations (T2*: 5-20 ms), depending on signal-to-noise ratio (SNR; range: 8-233) with significant (P < 0.05) difference between actual and predicted values. The MAP method performed well (error < 10%) at high SNR (>100), but resulted in severe estimation errors at low SNR (<50). The EXP model resulted in significant measurement differences (P < 0.05) compared with all other methods, irrespective of SNR. In vivo T2* values ranged from 3.1 to 53.6 ms, depending on the amount of iron overload and implemented analysis method. The BEXP (range: 3.7-50 ms) and CEXP (range: 3.8-53.6 ms) models, and the AVG (range: 3.2-38.8 ms) and MED (range: 3.1-38.5 ms) methods provided more accurate measurements than the EXP model (range: 3.1-18.3 ms) and MAP (range: 3.8-53.6 ms) method, respectively (P < 0.05). The BEXP and CEXP models provided very similar measurements (P > 0.87). Similarly, the AVG and MED methods provided very similar results (P > 0.97), with slightly better performance of the AVG method.Conclusion: Different analysis techniques show different performances based on the fitting model and signal calculation method. Based on this study, the CEXP model and AVG method are recommended due to simpler implementation and less influence by the selected analysis region. J. Magn. Reson. Imaging 2016;44:1448-1455. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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