"Same-patient processing" for multiple cardiac SPECT studies. 2. Improving quantification repeatability.
Objectives: This paper investigates the ability of grouped quantification (an expression of the same-patient processing approach, or SPP) to improve repeatability of measurements in patients with multiple SPECT studies, and evaluates its performance compared to standard quantification in a populatio...
| Published in: | Journal of Nuclear Cardiology Vol. 23; no. 6; pp. 1442 - 1454 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | equations & formulas research tables/charts Journal Article |
| Published: |
Elsevier B.V.
Dec2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119576482&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119576482 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10713581 1YCL jtl: Journal of Nuclear Cardiology issn: 10713581 maglogo: N pubinfo: dt: Dec2016 vid: 23 iid: 6 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 119576482 119576482 144189058 NLM27743297 119576482 10.1007/s12350-016-0674-1 NLM27743297 119576482 ppf: 1442 ppct: 12 formats: tig: atl: "Same-patient processing" for multiple cardiac SPECT studies. 2. Improving quantification repeatability. aug: au: Germano, Guido Kavanagh, Paul Ruddy, Terrence Wells, R. Xu, Yuan Berman, Daniel Slomka, Piotr Kavanagh, Paul B Ruddy, Terrence D Wells, R Glenn Berman, Daniel S Slomka, Piotr J affil: Department of Medicine , Cedars-Sinai Medical Center , Los Angeles USA sug: subj: Ventricular Dysfunction, Left Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography Methods Image Enhancement Methods Coronary Arteriosclerosis Tomography, Emission-Computed, Single-Photon Methods Heart Function Tests Methods Heart Ventricle Sensitivity and Specificity Middle Age Female Stroke Volume Coronary Arteriosclerosis Complications Reproducibility of Results Ventricular Dysfunction, Left Etiology Male Funding Source Human Middle Aged: 45-64 years Female Male ab: Objectives: This paper investigates the ability of grouped quantification (an expression of the same-patient processing approach, or SPP) to improve repeatability of measurements in patients with multiple SPECT studies, and evaluates its performance compared to standard quantification in a population of 100 patients undergoing rest, stress, gated rest, and gated stress SPECT MPI. All acquisitions were performed twice, back-to-back, for a total of 800 image datasets (8 per patient).Methods: Each dataset was automatically processed (a) independently, using standard quantitative software, and (b) as a group, together with the other 7 datasets belonging to the same patient, using an SPP-modified version of the software that registered the images to one another using a downhill simplex algorithm for the search of optimal translation, rotation, and scaling parameters.Results: Overall, grouped quantification resulted in significantly lower differences between repeated measurements of stress ungated volumes (1.40 ± 2.76 mL vs 3.33 ± 5.06 mL, P < .05), end-diastolic volumes (1.78 ± 2.78 vs 3.49 ± 5.35 mL, P < .05), end-systolic volumes (1.17 ± 1.96 vs 2.44 ± 3.35 mL, P < .05), and LVEFs (-0.45 ± 2.29% vs -1.16 ± 3.30%, P < .05). Additionally, grouped quantification produced better repeatability (lower repeatability coefficients) for stress and rest ungated volumes (5.4 vs 9.9 and 5.2 vs 13.1, respectively), stress TPD (2.6 vs 3.6), stress and rest end-diastolic volumes (5.5 vs 10.5 and 7.2 vs 14.7, respectively), stress and rest end-systolic volumes (3.8 vs 6.6 and 5.3 vs 10.3, respectively), stress and rest LVEFs (4.5 vs 6.5 and 4.7 vs 8.2, respectively), and rest total motion deficit (5.6 vs 9.6).Conclusion: It is possible to improve the repeatability of quantitative measurements of parameters of myocardial perfusion and function derived from SPECT MPI studies of a same patient by group processing of image datasets belonging to that patient. This application of the same-patient processing approach is an extension of the "paired processing" technique already described by our group, and can be performed in automated fashion through incorporation in the quantitative algorithm. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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