Quantitative CT characterization of pediatric lung development using routine clinical imaging.
Background: The use of quantitative CT analysis in children is limited by lack of normal values of lung parenchymal attenuation. These characteristics are important because normal lung development yields significant parenchymal attenuation changes as children age.Objective: To perform quantitative c...
| Publicado en: | Pediatric Radiology Vol. 46; no. 13; pp. 1804 - 1813 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=119576959&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 119576959 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Dec2016 vid: 46 iid: 13 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 119576959 119576959 144017897 NLM27576458 10.1007/s00247-016-3686-8 NLM27576458 119576959 ppf: 1804 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Quantitative CT characterization of pediatric lung development using routine clinical imaging. aug: au: Stein, Jill Walkup, Laura Brody, Alan Fleck, Robert Woods, Jason Stein, Jill M Walkup, Laura L Brody, Alan S Fleck, Robert J Woods, Jason C affil: Department of Radiology , Cincinnati Children's Hospital Medical Center , 3333 Burnet Ave. Cincinnati 45229 USA sug: subj: Lung Tomography, X-Ray Computed Methods Lung Volume Measurements Child, Preschool Child Female Male Infant, Newborn Radiography, Thoracic Infant Reference Values Retrospective Design Clinical Assessment Tools Scales Child, Preschool: 2-5 years Child: 6-12 years Infant, Newborn: birth-1 month Infant: 1-23 months Female Male ab: Background: The use of quantitative CT analysis in children is limited by lack of normal values of lung parenchymal attenuation. These characteristics are important because normal lung development yields significant parenchymal attenuation changes as children age.Objective: To perform quantitative characterization of normal pediatric lung parenchymal X-ray CT attenuation under routine clinical conditions in order to establish a baseline comparison to that seen in pathological lung conditions.Materials and Methods: We conducted a retrospective query of normal CT chest examinations in children ages 0-7 years from 2004 to 2014 using standard clinical protocol. During these examinations semi-automated lung parenchymal segmentation was performed to measure lung volume and mean lung attenuation.Results: We analyzed 42 CT examinations in 39 children, ages 3 days to 83 months (mean ± standard deviation [SD] = 42 ± 27 months). Lung volume ranged 0.10-1.72 liters (L). Mean lung attenuation was much higher in children younger than 12 months, with values as high as -380 Hounsfield units (HU) in neonates (lung volume 0.10 L). Lung volume decreased to approximately -650 HU by age 2 years (lung volume 0.47 L), with subsequently slower exponential decrease toward a relatively constant value of -860 HU as age and lung volume increased.Conclusion: Normal lung parenchymal X-ray CT attenuation decreases with increasing lung volume and age; lung attenuation decreases rapidly in the first 2 years of age and more slowly thereafter. This change in normal lung attenuation should be taken into account as quantitative CT methods are translated to pediatric pulmonary imaging. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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