Reduced Hemispheric Asymmetry of White Matter Microstructure in Autism Spectrum Disorder.
<bold>Objective: </bold>Many past studies have suggested atypical functional and anatomical hemispheric asymmetries in autism spectrum disorder (ASD). However, almost all of these have examined only language-related asymmetries. Here, we conduct a comprehensive investigation of microstructural asymm...
| Published in: | Journal of the American Academy of Child & Adolescent Psychiatry Vol. 55; no. 12; pp. 1073 - 1081 |
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| Main Authors: | , , , |
| Format: | journal article |
| Published: |
Elsevier B.V.
Dec2016
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=119583488&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 119583488 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 08908567 JAM jtl: Journal of the American Academy of Child & Adolescent Psychiatry issn: 08908567 maglogo: N pubinfo: dt: Dec2016 vid: 55 iid: 12 pid: 467 pub: Elsevier B.V. artinfo: ui: 119583488 10.1016/j.jaac.2016.09.491 ppf: 1073 ppct: 8 formats: tig: atl: Reduced Hemispheric Asymmetry of White Matter Microstructure in Autism Spectrum Disorder. aug: au: Carper, Ruth A. DeJesus, Shannon Yandall Müller, Ralph-Axel Treiber, Jeffrey M. affil: Brain Development Imaging Laboratory at San Diego State University, San Diego, CA School of Medicine, University of California, San Diego su: Autism spectrum disorders Language disorders Psychology White matter (Nerve tissue) Brain function localization Anisotropy Brain Cerebral dominance Magnetic resonance imaging Research funding sug: subj: Autism spectrum disorders Language disorders Psychology Diagnostic Imaging Centers White matter (Nerve tissue) Brain function localization Anisotropy Brain Cerebral dominance Magnetic resonance imaging Research funding keyword: asymmetry autism diffusion tensor imaging MRI white matter asymmetry autism diffusion tensor imaging MRI white matter ab: <bold>Objective: </bold>Many past studies have suggested atypical functional and anatomical hemispheric asymmetries in autism spectrum disorder (ASD). However, almost all of these have examined only language-related asymmetries. Here, we conduct a comprehensive investigation of microstructural asymmetries across a large number of fiber tracts in ASD.<bold>Method: </bold>We used diffusion tensor imaging for a comprehensive investigation of anatomical white matter asymmetries across the entire white matter skeleton, using tract-based spatial statistics in 41 children and adolescents with ASD and a matched group of 44 typically developing (TD) participants.<bold>Results: </bold>We found significant asymmetries in the TD group, being rightward for fractional anisotropy and leftward for mean diffusivity (with concordant asymmetries for radial and axial diffusivity). These asymmetries were significantly reduced in the group with ASD: in whole brain analysis for fractional anisotropy, and in a region where several major association and projection tracts travel in close proximity within occipital white matter for mean diffusivity, axial diffusivity, and radial diffusivity. No correlations between global white matter asymmetry and age or socio-communicative abilities were detected.<bold>Conclusion: </bold>Our findings in TD children and adolescents can be interpreted as reflecting different processing modes (more integrative in the right and more specialized in the left hemisphere). These asymmetries and the "division of labor" between hemispheres implied by them appear to be diminished in autism spectrum disorder. pubtype: Academic Journal doctype: journal article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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